Autophagy Regulates the Survival of Hair Cells and Spiral Ganglion Neurons in Cases of Noise, Ototoxic Drug, and Age-Induced Sensorineural Hearing Loss
机构：[1]State Key Laboratory of Bioelectronics, School of Life Sciences and Technology, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China,[2]Department of Otolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China,[3]Department of Ambulatory Medicine, The First Medical Center of PLA General Hospital, Beijing, China,[4]Department of Otolaryngology Head and Neck Surgery, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, China,[5]Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, China,[6]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China,[7]Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing, China
Inner ear hair cells (HCs) and spiral ganglion neurons (SGNs) are the core components of the auditory system. However, they are vulnerable to genetic defects, noise exposure, ototoxic drugs and aging, and loss or damage of HCs and SGNs results in permanent hearing loss due to their limited capacity for spontaneous regeneration in mammals. Many efforts have been made to combat hearing loss including cochlear implants, HC regeneration, gene therapy, and antioxidant drugs. Here we review the role of autophagy in sensorineural hearing loss and the potential targets related to autophagy for the treatment of hearing loss.
基金：
This work was supported by the Strategic Priority Research
Program of the Chinese Academy of Sciences (XDA16010303),
National Key R&D Program of China (No. 2017YFA0103903),
the National Natural Science Foundation of China (Nos.
82030029, 81970882, and 82071055), Natural Science Foundation
from Jiangsu Province (BE2019711), and the Shenzhen
Fundamental Research Program (JCYJ20190814093401920).
第一作者机构：[1]State Key Laboratory of Bioelectronics, School of Life Sciences and Technology, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China,[2]Department of Otolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China,
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Bioelectronics, School of Life Sciences and Technology, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China,[5]Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, China,[6]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China,[7]Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Guo Lingna,Cao Wei,Niu Yuguang,et al.Autophagy Regulates the Survival of Hair Cells and Spiral Ganglion Neurons in Cases of Noise, Ototoxic Drug, and Age-Induced Sensorineural Hearing Loss[J].FRONTIERS IN CELLULAR NEUROSCIENCE.2021,15:doi:10.3389/fncel.2021.760422.
APA：
Guo, Lingna,Cao, Wei,Niu, Yuguang,He, Shuangba,Chai, Renjie&Yang, Jianming.(2021).Autophagy Regulates the Survival of Hair Cells and Spiral Ganglion Neurons in Cases of Noise, Ototoxic Drug, and Age-Induced Sensorineural Hearing Loss.FRONTIERS IN CELLULAR NEUROSCIENCE,15,
MLA：
Guo, Lingna,et al."Autophagy Regulates the Survival of Hair Cells and Spiral Ganglion Neurons in Cases of Noise, Ototoxic Drug, and Age-Induced Sensorineural Hearing Loss".FRONTIERS IN CELLULAR NEUROSCIENCE 15.(2021)
