Background: To explore the association of chronic rhinosinusitis (CRS) with bronchial asthma (BA) as well as its severity. Methods: A comprehensive database search will be performed from PubMed, Embase, Cochrane Library, and Web of science for related literatures. Heterogeneity test will be used to assess each outcome indicator. If heterogeneity statistics I-2 >= 50%, the random effects model will be applied; if I-2 < 50%, the fixed effects model will be performed. Sensitivity analysis will be performed in all models. STATA 15.0 software (Stata Corporation, College Station, TX) will be used for statistical analysis. Risk ratio (RR) will be used as the effect size for enumeration data. P Conclusion: This study will evaluate the association of CRS with the prevalence of BA as well as its severity. OSF registration number: 10.17605/OSF.IO/GCTM9.
基金：
Beijing Health Bureau Program for High Level Talents [2015-3-020]
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Key Lab Otolaryngol Head & Neck Surg,Minist Educ, 1 Dongjiao Minxiang, Beijing 100730, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Key Lab Otolaryngol Head & Neck Surg,Minist Educ, 1 Dongjiao Minxiang, Beijing 100730, Peoples R China[*1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education of China, No.1 Dongjiao Minxiang, Dongcheng District, Beijing 100730, PR China
推荐引用方式(GB/T 7714)：
Pan Yangwang,Zang Hongrui.Association of chronic rhinosinusitis with bronchial asthma and its severity A protocol for systematic review and meta-analysis[J].MEDICINE.2021,100(9):doi:10.1097/MD.0000000000024772.
APA：
Pan, Yangwang&Zang, Hongrui.(2021).Association of chronic rhinosinusitis with bronchial asthma and its severity A protocol for systematic review and meta-analysis.MEDICINE,100,(9)
MLA：
Pan, Yangwang,et al."Association of chronic rhinosinusitis with bronchial asthma and its severity A protocol for systematic review and meta-analysis".MEDICINE 100..9(2021)
