机构:[1]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore[2]Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUSMedicalSchool, Singapore[3]Centre for Quantitative Medicine, Duke-NUSMedical School, Singapore[4]Department of Ophthalmology, Yonsei University College of Medicine, Seoul,Republic of Korea[5]Aditya Jyot Foundation for Twinkling Little Eyes, Mumbai, Maharashtra, India[6]Beijing Institute of Ophthalmology, Beijing Ophthalmology & Visual Sciences KeyLaboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital MedicalUniversity, Beijing, China研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[7]Suraj Eye Institute, Nagpur, Maharashtra, India[8]Department of Epidemiology and Public Health, Graduate School of MedicalSciences, Kyushu University, Fukuoka, Japan[9]Department of Ophthalmology, Graduate School of Medical Sciences, KyushuUniversity, Fukuoka, Japan[10]Department of Medicine, Yong Loo Lin School of Medicine, National UniversitySingapore, Singapore[11]Department of Ophthalmology, Kangbuk Samsung Hospital, SungkyunkwanUniversity School of Medicine, Seoul, South Korea[12]Ufa Eye Research Institute, Ufa, Russia[13]Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, India[14]Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University,Mannheim, Germany
Background/aims Obesity is a well-known risk factor for diabetes, but its association with diabetic retinopathy (DR) is inconclusive, in particular in Asians. We aimed to assess whether body mass index (BMI) is associated with the presence and severity of DR in Asian populations with diabetes. Methods Pooled analysis of individual-level cross-sectional data from 10 010 adults with diabetes who participated in 12 population-based studies conducted in China, India, Japan, Russia (Asian), Singapore and South Korea that were part of the Asian Eye Epidemiology Consortium (AEEC). BMI was calculated as weight in kilograms divided by height in square metres and categorised into normal (<25 kg/m(2), reference), overweight (25-29.9 kg/m(2)) and obese (>= 30 kg/m(2)). Any-DR (n=1669) and vision-threatening DR (VTDR, n=489) were assessed from digital retinal photographs and graded according to standard protocols. Each study was analysed separately using multivariable logistic regression models adjusted for age, sex, haemoglobin A1c%, systolic blood pressure and diabetes duration, and the estimated odds ratios (ORs) and 95% confidence interval (CIs) from all studies were then combined using random-effects models. Results In multivariable models, obesity showed a significant inverse association with any-DR (pooled OR (95% CI) =0.74 (0.59 to 0.91)) and VTDR (0.75 (0.60 to 0.93)). Similarly, in continuous analysis, BMI showed a significant inverse association with both any-DR (0.93 (0.87 to 0.99)) and VTDR (0.79 (0.68 to 0.92) per SD increase). Overweight did not show a significant association with any-DR. Conclusions Among Asian adults with diabetes, both BMI and obesity showed an inverse association with DR. These findings warrant confirmation in further longitudinal studies.
基金:
National Medical Research Council,
NMRC/STaR/003/2008, NMRC/0796/2003 and NMRC/1249/2010.
第一作者机构:[1]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore[2]Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUSMedicalSchool, Singapore[*1]Singapore Eye Research Institute, Singapore, Singapore
通讯作者:
通讯机构:[1]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore[2]Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUSMedicalSchool, Singapore[*1]Singapore Eye Research Institute, Singapore, Singapore
推荐引用方式(GB/T 7714):
Sabanayagam Charumathi,Sultana Rehena,Banu Riswana,et al.Association between body mass index and diabetic retinopathy in Asians: the Asian Eye Epidemiology Consortium (AEEC) study[J].BRITISH JOURNAL OF OPHTHALMOLOGY.2022,106(7):980-986.doi:10.1136/bjophthalmol-2020-318208.
APA:
Sabanayagam, Charumathi,Sultana, Rehena,Banu, Riswana,Rim, Tyler,Tham, Yih Chung...&Jonas, Jost B..(2022).Association between body mass index and diabetic retinopathy in Asians: the Asian Eye Epidemiology Consortium (AEEC) study.BRITISH JOURNAL OF OPHTHALMOLOGY,106,(7)
MLA:
Sabanayagam, Charumathi,et al."Association between body mass index and diabetic retinopathy in Asians: the Asian Eye Epidemiology Consortium (AEEC) study".BRITISH JOURNAL OF OPHTHALMOLOGY 106..7(2022):980-986