Myocardial infarction (MI) is one of the most common causes of death worldwide. A metabolomic approach based on an ultra-high performance liquid chromatography-Orbitrap analytical method was established to analyze the metabolites and to investigate the therapeutic mechanism of colchicine. Forty-six biomarkers were significantly changed between the sham group and the MI group. Thirty-five metabolites were increased and 11 were decreased in MI rats, and colchicine reversed all of them. Pathway analysis showed that the TCA cycle, alanine, aspartate and glutamate metabolism, glycerophospholipid metabolism, aminoacyl-tRNA biosynthesis, glyoxylate and dicarboxylate metabolism and arginine biosynthesis were altered in the MI group. Ingenuity pathway function and network analysis showed that colchicine improved MI through regulation of cardiac beta-adrenergic signaling and cardiac hypertrophy signaling. The present study provided a useful approach for exploring the mechanism of MI and evaluating the efficacy of colchicine.
基金：
Key Disciplines Group Construction Project of Pudong Health Bureau of Shanghai [PWZxq2017-05]; Outstanding Clinical Discipline Project of Shanghai Pudong [PWYgy2018-05]; Top-level Clinical Discipline Project of Shanghai Pudong District [PWYgf2018-02]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|4 区医学
小类|4 区生化研究方法4 区生化与分子生物学4 区分析化学4 区药学
最新[2025]版：
大类|4 区医学
小类|4 区生化研究方法4 区生化与分子生物学4 区分析化学4 区药学
JCR分区：
出版当年[2019]版：
Q3CHEMISTRY, ANALYTICALQ4BIOCHEMICAL RESEARCH METHODSQ4BIOCHEMISTRY & MOLECULAR BIOLOGYQ4PHARMACOLOGY & PHARMACY
最新[2023]版：
Q3CHEMISTRY, ANALYTICALQ3PHARMACOLOGY & PHARMACYQ4BIOCHEMICAL RESEARCH METHODSQ4BIOCHEMISTRY & MOLECULAR BIOLOGY
第一作者机构：[1]Tongji Univ, Sch Med, East Hosp, Dept Cardiovasc Med, 150 Jimo Rd, Shanghai 200120, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Tongji Univ, Sch Med, East Hosp, Dept Cardiovasc Med, 150 Jimo Rd, Shanghai 200120, Peoples R China[3]Shanghai Univ Tradit Chinese Med, Peoples Hosp 7, Dept Cardiol, 358 Datong Rd, Shanghai 200137, Peoples R China[*1]Department of Cardiovascular Medicine, East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai 200120, China.[*2]Department of Cardiology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, No. 358 Datong Road, Pudong New Area, Shanghai City 200137, China.
推荐引用方式(GB/T 7714)：
Wen Wei,Zhang Zhongxiao,Jiang Bing,et al.Orbitrap-MS-based untargeted metabolomics study on the therapeutic effect of colchicine on myocardial infarction[J].BIOMEDICAL CHROMATOGRAPHY.2021,35(9):doi:10.1002/bmc.5148.
APA：
Wen, Wei,Zhang, Zhongxiao,Jiang, Bing&Hao, Ying.(2021).Orbitrap-MS-based untargeted metabolomics study on the therapeutic effect of colchicine on myocardial infarction.BIOMEDICAL CHROMATOGRAPHY,35,(9)
MLA：
Wen, Wei,et al."Orbitrap-MS-based untargeted metabolomics study on the therapeutic effect of colchicine on myocardial infarction".BIOMEDICAL CHROMATOGRAPHY 35..9(2021)
