Exosomes (Exos) are nanosized vesicles (around 100 nm) that recently serve as a promising drug carrier with high biocompatibility and low immunogenicity. Previous studies showed that Exos secreted from mesenchymal stem cells (MSCs) provide protection for concanavalin A (Con A)-induced liver injury. In this study, the protective effect of Exos is confirmed, and dexamethasone (DEX)-incorporated Exos named Exo@DEX are prepared. It is then investigated whether Exo@DEX can function more efficiently compared to free drugs and naive Exos in a Con A-induced autoimmune hepatitis (AIH) mouse model. The results show that Exo@DEX efficiently improves the accumulation of DEX in AIH in the liver. These data suggest that Exo@DEX is a promising drug carrier for AIH and could have applications in other diseases.
基金：
National Natural Science Foundation of China (Grant Nos. 81871912
and 81970530) and Shanghai Municipal Health Bureau Key
Disciplines Grant (Grant No. ZK2019C012).
第一作者机构：[1]Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Gastroenterol, Shanghai, Peoples R China[2]Jiangsu Univ, Sch Med, Zhenjiang, Jiangsu, Peoples R China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zhao Jiawei,Li Yue,Jia Rongrong,et al.Mesenchymal Stem Cells-Derived Exosomes as Dexamethasone Delivery Vehicles for Autoimmune Hepatitis Therapy[J].FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY.2021,9:doi:10.3389/fbioe.2021.650376.
APA：
Zhao, Jiawei,Li, Yue,Jia, Rongrong,Wang, Jinghui,Shi, Min&Wang, Yugang.(2021).Mesenchymal Stem Cells-Derived Exosomes as Dexamethasone Delivery Vehicles for Autoimmune Hepatitis Therapy.FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,9,
MLA：
Zhao, Jiawei,et al."Mesenchymal Stem Cells-Derived Exosomes as Dexamethasone Delivery Vehicles for Autoimmune Hepatitis Therapy".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 9.(2021)
