Frequent Recurrence of Sinonasal Inverted Papilloma With Carcinoma In Situ in a Multifocal Attachment Pattern: A Case Report and Review of the Literature
Sinonasal inverted papilloma (SIP) is a benign tumor originating from the nasal cavity and paranasal sinuses. Sinonasal inverted papilloma is characterized by local infiltration, high recurrence, and malignant transformation, and its associated dysplasia ranges from mild, moderate, severe, carcinoma in situ (CIS) to invasive squamous cell carcinoma. Sinonasal inverted papilloma with carcinoma in situ (IPwCIS) is the highest degree of dysplasia, which is a stage of malignant transformation of IP. Surgical excision and proper adjuvant therapy can help reduce recurrence rates and suppress further deterioration. In this study, we present a patient with IPwCIS who developed 3 recurrences with a multifocal attachment pattern in less than 18 months. We report the clinical manifestations, development, and treatment process in detail. We also performed a literature review to analyze the characteristics of the disease. Despite comprehensive treatment methods, tumor recurrence and further deterioration of IPwCIS persist.
基金：
Beijing Municipal Administration of Hospitals' Ascent Plan [DFL20150202]; Clinical Medicine Development of Special Funding Support in Beijing Tongren Hospital, Capital Medical University [trzdyxzy201702]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81770977]; Beijing Municipal Science & Technology CommissionBeijing Municipal Science & Technology Commission [Z181100001718103]
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, 1 Dongjiaominxiang, Beijing 100730, Peoples R China[2]Qingdao Univ, Yantai Yuhuangding Hosp, Dept Otolaryngol Head & Neck Surg, Yantai, Shandong, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, 1 Dongjiaominxiang, Beijing 100730, Peoples R China[*1]Department of Otolaryngology—Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang, Dongcheng District, Beijing 100730, People’s Republic of China.
推荐引用方式(GB/T 7714)：
Wang Yan,Cui Shunjiu,Li Cheng,et al.Frequent Recurrence of Sinonasal Inverted Papilloma With Carcinoma In Situ in a Multifocal Attachment Pattern: A Case Report and Review of the Literature[J].ENT-EAR NOSE & THROAT JOURNAL.2023,102(6):397-401.doi:10.1177/0145561321991344.
APA：
Wang, Yan,Cui, Shunjiu,Li, Cheng&Zhou, Bing.(2023).Frequent Recurrence of Sinonasal Inverted Papilloma With Carcinoma In Situ in a Multifocal Attachment Pattern: A Case Report and Review of the Literature.ENT-EAR NOSE & THROAT JOURNAL,102,(6)
MLA：
Wang, Yan,et al."Frequent Recurrence of Sinonasal Inverted Papilloma With Carcinoma In Situ in a Multifocal Attachment Pattern: A Case Report and Review of the Literature".ENT-EAR NOSE & THROAT JOURNAL 102..6(2023):397-401
