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An ocular glymphatic clearance system removes β-amyloid from the rodent eye

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收录情况: ◇ SCIE ◇ 自然指数

机构: [1]Univ Copenhagen, Ctr Translat Neuromed, Fac Med & Hlth Sci, Blegdamsvej 3B, DK-2200 Copenhagen N, Denmark [2]Univ Rochester, Sch Med, Ctr Translat Neuromed, Elmwood Ave 601, Rochester, NY 14642 USA [3]Univ Calif Berkeley, Ctr Eye Dis & Dev, Vis Sci Grad Program, Berkeley, CA 94720 USA [4]Univ Calif Berkeley, Sch Optometry, Berkeley, CA 94720 USA [5]Ludwig Maximilians Univ Munich LMU, Inst Stroke & Dementia Res, Klinikum Univ Munchen, D-81377 Munich, Germany [6]Helmholtz Ctr Munchen, ITERM, D-85764 Munich, Germany [7]Univ Rochester, Med Ctr, Dept Ophthalmol, Rochester, NY 14642 USA [8]Haukeland Hosp, Dept Ophthalmol, Jonas Lies Vei 65, N-5021 Bergen, Norway
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关键词: OPTIC-NERVE HEAD GANGLION-CELL DEGENERATION INTRAOCULAR-PRESSURE MOUSE MODEL INTRACRANIAL-PRESSURE LAMINA-CRIBROSA DISC EDEMA GLAUCOMA BRAIN FLUID

摘要:
Despite high metabolic activity, the retina and optic nerve head lack traditional lymphatic drainage. We here identified an ocular glymphatic clearance route for fluid and wastes via the proximal optic nerve in rodents. beta-amyloid (A beta) was cleared from the retina and vitreous via a pathway dependent on glial water channel aquaporin-4 (AQP4) and driven by the ocular-cranial pressure difference. After traversing the lamina barrier, intra-axonal A beta was cleared via the perivenous space and subsequently drained to lymphatic vessels. Light-induced pupil constriction enhanced efflux, whereas atropine or raising intracranial pressure blocked efflux. In two distinct murine models of glaucoma, A. leaked from the eye via defects in the lamina barrier instead of directional axonal efflux. The results suggest that, in rodents, the removal of fluid and metabolites from the intraocular space occurs through a glymphatic pathway that might be impaired in glaucoma.

基金:

基金编号: 742112 R01NS100366 RF1AG057575 R01EY028995 912179 912230 742112

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出版当年[2019]版:
大类 | 1 区 医学
小类 | 1 区 细胞生物学 1 区 医学:研究与实验
最新[2023]版:
大类 | 1 区 医学
小类 | 1 区 细胞生物学 1 区 医学:研究与实验
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出版当年[2018]版:
Q1 CELL BIOLOGY Q1 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版:
Q1 CELL BIOLOGY Q1 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子: 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

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第一作者机构: [1]Univ Copenhagen, Ctr Translat Neuromed, Fac Med & Hlth Sci, Blegdamsvej 3B, DK-2200 Copenhagen N, Denmark [2]Univ Rochester, Sch Med, Ctr Translat Neuromed, Elmwood Ave 601, Rochester, NY 14642 USA
通讯作者:
通讯机构: [1]Univ Copenhagen, Ctr Translat Neuromed, Fac Med & Hlth Sci, Blegdamsvej 3B, DK-2200 Copenhagen N, Denmark [*1]Univ Copenhagen, Ctr Translat Neuromed, Fac Med & Hlth Sci, Blegdamsvej 3B, DK-2200 Copenhagen N, Denmark [2]Univ Rochester, Sch Med, Ctr Translat Neuromed, Elmwood Ave 601, Rochester, NY 14642 USA [*2]Univ Rochester, Sch Med, Ctr Translat Neuromed, Elmwood Ave 601, Rochester, NY 14642 USA [3]Univ Calif Berkeley, Ctr Eye Dis & Dev, Vis Sci Grad Program, Berkeley, CA 94720 USA [*3]Univ Calif Berkeley, Ctr Eye Dis & Dev, Vis Sci Grad Program, Berkeley, CA 94720 USA [4]Univ Calif Berkeley, Sch Optometry, Berkeley, CA 94720 USA [*4]Univ Calif Berkeley, Sch Optometry, Berkeley, CA 94720 USA
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