机构：[1]Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USA; Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pediat, Piscataway, NJ 08854 USA
The Ebf transcription factors play important roles in the developmental processes of many tissues. We have shown previously that four members of the Ebf family are expressed during mouse retinal development and are both necessary and sufficient to specify multiple retinal cell fates. Here we describe the changes in cell differentiation and retinal ganglion cell (RGC) projection in Ebf1 knockout mice. Analysis of marker expression in Ebf1 null mutant retinas reveals that loss of Ebf1 function causes a significant increase of Muller cells. Moreover, there is an obvious decrease of ipsilateral and retinoretinal projections of RGC axons at the optic chiasm, whereas the contralateral projection significantly increases in the mutant mice. These data together suggests that Ebf1 is required for suppressing the Muller cell fate during retinogenesis and important for the correct topographic projection of RGC axons at the optic chiasm. (C) 2011 Elsevier Inc. All rights reserved.
基金：
National Institutes of Health [EY012020, EY020849]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2010]版：
大类|3 区生物
小类|3 区生物物理4 区生化与分子生物学
最新[2023]版：
大类|3 区生物学
小类|3 区生物物理4 区生化与分子生物学
第一作者：
第一作者机构：[1]Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USA; Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pediat, Piscataway, NJ 08854 USA[*1]Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Ctr Adv Biotechnol & Med, 679 Hoes Lane W, Piscataway, NJ 08854 USA
通讯作者：
通讯机构：[*1]Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Ctr Adv Biotechnol & Med, 679 Hoes Lane W, Piscataway, NJ 08854 USA
推荐引用方式(GB/T 7714)：
Jin Kangxin,Xiang Mengqing.Ebf1 deficiency causes increase of Muller cells in the retina and abnormal topographic projection at the optic chiasm[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2011,414(3):539-544.doi:10.1016/j.bbrc.2011.09.108.
APA：
Jin, Kangxin&Xiang, Mengqing.(2011).Ebf1 deficiency causes increase of Muller cells in the retina and abnormal topographic projection at the optic chiasm.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,414,(3)
MLA：
Jin, Kangxin,et al."Ebf1 deficiency causes increase of Muller cells in the retina and abnormal topographic projection at the optic chiasm".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 414..3(2011):539-544
