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Cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in the treatment of stage IE/IIE extranodal natural killer/T cell lymphoma, nasal type: 13-year follow-up in 135 patients

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机构: [1]Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol S China, Dept Radiat Oncol, Guangzhou 510060, Guangdong, Peoples R China [2]Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol S China, Dept Hematol Oncol, Guangzhou 510060, Guangdong, Peoples R China [3]Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol S China, Dept Med Oncol, Guangzhou 510060, Guangdong, Peoples R China
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关键词: NON-HODGKINS-LYMPHOMA BARR-VIRUS-DNA PHASE-II RADIOTHERAPY CHEMOTHERAPY PIRARUBICIN WORKSHOP SURVIVAL REGIMENS

摘要:
We conducted a retrospective study of 135 patients of stage IE/IIE extranodal natural killer/T cell lymphoma, nasal type (ENKTL) treated with CHOP as induction chemotherapy to find some valuable prognostic factors and analyze the usefulness of International Prognostic Index (IPI) and Korean Prognostic Index (KPI) in predicting prognosis. Most of the patients were in the low-risk group (IPI score 0-1). Complete remission (CR) after induction chemotherapy was achieved in 31.8 % of the patients, which increased to 69.6 % after radiotherapy. The 2-, 5-, and 10-year overall survival (OS) rates were 60, 48, and 43 %, respectively. Patients with better performance status (ECOG 0-1), normal serum LDH level, without local invasiveness, low KPI scores, and IPI score of 0 had significantly better overall survival (P < 0.05) in univariate analysis. Using multivariate analysis, we identified serum LDH level, ECOG PS score and local invasiveness to be independent prognostic factors. In conclusion, ENKTL is an aggressive lymphoma that shows heterogeneity. The IPI and KPI score systems should be improved further to classify patients into different groups, and should be validated in larger prospective trials. Due to the multi-drug resistance mechanism of ENKTL, CHOP is no longer the state of art and novel drugs should be incorporated into future treatments.

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出版当年[2011]版:
大类 | 4 区 医学
小类 | 4 区 血液学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 血液学
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出版当年[2010]版:
Q4 HEMATOLOGY
最新[2023]版:
Q3 HEMATOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2010版] 出版当年五年平均 出版前一年[2009版] 出版后一年[2011版]

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第一作者机构: [2]Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol S China, Dept Hematol Oncol, Guangzhou 510060, Guangdong, Peoples R China
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通讯机构: [1]Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol S China, Dept Radiat Oncol, Guangzhou 510060, Guangdong, Peoples R China [*1]Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol S China, Dept Radiat Oncol, Guangzhou 510060, Guangdong, Peoples R China
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