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Influence of Goniotomy Size on Treatment Safety and Efficacy for Primary Open-Angle Glaucoma: A Multicenter Study

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机构: [1]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong, China. [2]Department of Ophthalmology, Chengdu First People's Hospital, Chengdu, Sichuan, China [3]Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, Japan [4]Department of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China [5]Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu, Sichuan, China [6]Jinan Mingshui Eye Hospital, Jinan, Shandong, China [7]Department of Ophthalmology, Handan City Eye Hospital (The Third Hospital of Handan), Handan, Hebei, China [8]Cangzhou Aier Eye Hospital, Aier Eye Hospital Group, Cangzhou, Hebei, China [9]Department of Ophthalmology, Shijiazhuang People's Hospital, Shijiazhuang, Hebei, China [10]Department of Ophthalmology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China [11]Department of Ophthalmology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China [12]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China [13]Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. [14]NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK [15]Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Republic of Singapore [16]International Eye Research Institute of The Chinese University of Hong Kong (Shenzhen), Shenzhen, China [17]Hamilton Glaucoma Center, Viterbi Family Department of Ophthalmology, and Shiley Eye Institute, University of California San Diego, La Jolla, CA, USA
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关键词: goniotomy minimally invasive glaucoma surgery primary open-angle glaucoma phacoemulsification

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To compare the efficacy and safety of 120°, 240°, and 360° goniotomy (GT) with or without phacoemulsification with intraocular lens implantation (PEI) for primary open-angle glaucoma (POAG).Multicenter, retrospective, comparative, non-randomized interventional study.Patients diagnosed with POAG who underwent GT with or without PEI were included, and divided into six groups: (1) standalone 120° GT, (2) standalone 240° GT, (3) standalone 360° GT, (4) PEI+120° GT, (5) PEI+240° GT, and (6) PEI+360° GT. Data on intraocular pressure (IOP), number of ocular hypotensive medications and complications were collected and compared. Success was defined as a postoperative IOP within the range of 6 to18 mmHg and a 20% reduction from baseline without further glaucoma surgery. Complete success and qualified success were defined as the above without and with ocular hypotensive medications, respectively.308 eyes of 231 patients were included with a mean follow-up of 14.4±8.6 months (6.0-48.0 months). There were no significant differences in the reductions in IOP and number of medications, cumulative survival probability for complete and qualified success rates among the three groups of standalone GT and PEI+GT. 360° GT group had the highest proportion of hyphema with or without PEI.120°, 240°, and 360° GT with or without PEI showed similar efficacy in reducing IOP and medications used in POAG. 360° GT with or without PEI was more likely to cause hyphema as compared with 120° or 240° GT. 120° GT with or without PEI was sufficient for treating POAG with or without cataract.Copyright © 2023. Published by Elsevier Inc.

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大类 | 1 区 医学
小类 | 1 区 眼科学
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大类 | 1 区 医学
小类 | 1 区 眼科学
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Q1 OPHTHALMOLOGY
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Q1 OPHTHALMOLOGY

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第一作者机构: [1]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong, China.
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通讯机构: [1]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong, China. [2]Department of Ophthalmology, Chengdu First People's Hospital, Chengdu, Sichuan, China [*1]Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, No.7, Jinsui Road, Guangzhou 510060, China [*2]Department of Ophthalmology, Chengdu First People's Hospital, Chengdu 610000, China
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