机构：[1]Department of Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.[2]Department of Pharmacy, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.[3]Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.[4]State Key Laboratory of Advanced Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.[5]Shenzhen Key Laboratory of Marine Biomedical Materials, CAS-HK Joint Lab of Biomaterials, The Key Laboratory of Biomedical Imaging Science and System, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.[6]School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong, 999077, China.[7]School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Sub-Lane Xiangshan, Hangzhou, 310024, China.浙江省肿瘤医院
Effective and precise treatment of breast cancer, particularly with bone
metastasis, remains a significant challenge. Here, a dual-gating strategy
combining locally delivered borate glass (BG) and ultrasound (US) is
developed for the precise and effective inhibition of breast cancer by targeting
transient receptor potential vanilloid 2 (TRPV2). The results demonstrate that
after local delivery of BG to the solid tumor, US effectively triggers calcium
overload by activating the overexpressed TRPV2 channels, leading to
mitochondrial autophagy and apoptosis in breast cancer cells, thereby
inhibiting tumor growth with high precision. These effects are validated in
subcutaneous, orthotopic, and TRPV2-overexpressing breast cancer mouse
models. In the bone metastasis model, BG combined with US treatment
simultaneously suppresses tumor growth and promotes bone regeneration.
Overall, this dual-gating strategy offers a safe and efficient approach for the
precise treatment of cancers with high TRPV2 expression and provides new
insights into the design and clinical translation of calcium-overload-based
cancer therapies.
基金：
Financial support from the National Natural Science Foundation of China
(Grant Nos. U23A20692, 32071344, 32371397), the National Key R&DProgram
of China (Grant No. 2021YFC2400500), the Shanghai Outstanding
Academic Leader, China (Grant No. 23XD1403400), and the Talent project
of Shanghai Tongren Hospital (Grant No. TRKYRCxx02).
第一作者机构：[1]Department of Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.[2]Department of Pharmacy, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.[2]Department of Pharmacy, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.[4]State Key Laboratory of Advanced Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.[7]School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Sub-Lane Xiangshan, Hangzhou, 310024, China.
推荐引用方式(GB/T 7714)：
Zhu Haihong,Ouyang Liping,Huang Yangguang,et al.Dual-Gating Strategy: Ultrasound Activation of TRPV2 Channels and Borate-Glass-Induced Calcium Overload for Tumor Suppression[J].Advanced Science (Weinheim, Baden-Wurttemberg, Germany).2025,12(16):e2414676.doi:10.1002/advs.202414676.
APA：
Zhu Haihong,Ouyang Liping,Huang Yangguang,Tan Ji,Liu Chunyu...&Liao Yun.(2025).Dual-Gating Strategy: Ultrasound Activation of TRPV2 Channels and Borate-Glass-Induced Calcium Overload for Tumor Suppression.Advanced Science (Weinheim, Baden-Wurttemberg, Germany),12,(16)
MLA：
Zhu Haihong,et al."Dual-Gating Strategy: Ultrasound Activation of TRPV2 Channels and Borate-Glass-Induced Calcium Overload for Tumor Suppression".Advanced Science (Weinheim, Baden-Wurttemberg, Germany) 12..16(2025):e2414676
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