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Advances in Neuromodulation Techniques for Aphasia Rehabilitation: A Comprehensive Review

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机构: [1]Second Rehabil Hosp Shanghai, Clin Res Ctr, Shanghai, Peoples R China [2]Renhe Hosp Baoshan Dist, Dept Rehabil Med, Shanghai, Peoples R China [3]Shanghai Jiao Tong Univ, Tongren Hosp, Dept Rehabil Med, Sch Med, Shanghai, Peoples R China [4]Shanghai Jiao Tong Univ, Sch Med, Yuanshen Rehabil Inst, Shanghai, Peoples R China [5]Shanghai Jiao Tong Univ, Natl Res Ctr Language & Well Being, Shanghai, Peoples R China
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关键词: Aphasia Rehabilitation Review Transcranial Direct Current Stimulation Transcranial Magnetic Stimulation

摘要:
Aphasia, a language impairment resulting from stroke or neurodegenerative disease, presents complex rehabilitation challenges. Recently, neuromodulation techniques such as transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS), and mirror neuron system (MNS) therapy have emerged as promising adjuncts to traditional speech-language therapy. This narrative review summarizes current advances in these 3 modalities. tDCS involves low-intensity electrical stimulation to modulate cortical excitability, with evidence supporting its use in post-stroke aphasia (PSA) and primary progressive aphasia (PPA). TMS, a magnetic stimulation technique, provides more precise cortical targeting through low-or high-frequency protocols and emerging paradigms such as intermittent theta-burst stimulation (iTBS). MNS therapy employs behavioral strategies like action observation and imitation to enhance motor-language pathways. The review also discusses the neural mechanisms underlying aphasia recovery, such as cortical reorganization and interhemispheric compensation, and examines the role of advanced tools such as functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) in guiding personalized treatment. Future directions include closed-loop stimulation, multimodal integration, and individualized protocols. This article aims to review recent developments in neuromodulation techniques for rehabilitating patients with aphasia, including transcranial direct current stimulation, transcranial magnetic stimulation, and mirror neuron system therapy.

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出版当年[2025]版:
大类 | 4 区 医学
小类 | 4 区 医学:研究与实验
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 医学:研究与实验
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出版当年[2023]版:
Q3 MEDICINE, RESEARCH & EXPERIMENTAL
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Q3 MEDICINE, RESEARCH & EXPERIMENTAL

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第一作者机构: [1]Second Rehabil Hosp Shanghai, Clin Res Ctr, Shanghai, Peoples R China
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通讯机构: [3]Shanghai Jiao Tong Univ, Tongren Hosp, Dept Rehabil Med, Sch Med, Shanghai, Peoples R China [4]Shanghai Jiao Tong Univ, Sch Med, Yuanshen Rehabil Inst, Shanghai, Peoples R China [5]Shanghai Jiao Tong Univ, Natl Res Ctr Language & Well Being, Shanghai, Peoples R China
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