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The mediation effects of white matter microstructural abnormalities on the associations between cerebral small vessel disease burden and cognitive impairment

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Pubmed体系：

收录情况： ◇ SCIE

作者：
Sui Chaofan[1,2] * ; Liang Changhu[1] * ; Gao Yian[1] ; Wang Na[1] ; Zhang Xinyue[1] ; Wang Yuanyuan[3] ; Zhang Nan[1] ; Che Yena[4] ; Feng Mengmeng[5] ; Xin Haotian[5] ; Li Jing[6] ; Guo Lingfei[1] ; Wen Hongwei[7] ;
机构： [1]Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Agingei, Ministry of Education, Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jing-wu Road, Jinan 250021, China [2]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China [3]Department of Radiology, Binzhou medical university, Guanhai Road No. 346, Yantai 264003, China [4]Department of Laboratory Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jing-wu Road, Jinan 250021, Shandong, China [5]Department of Radiology, Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, No. 45 Chang-chun St, Xicheng District, Beijing, China [6]Department of Radiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China [7]School of Medical Imaging, North Sichuan Medical College, Nanchong 637000, Sichuan, China
出处：
DOI： 10.1016/j.nbd.2025.107025
ISSN：

关键词： Cerebral small vessel disease Diffusion tensor imaging White matter microstructure Cognitive dysfunction

摘要：
White matter (WM) microstructural deterioration is associated with a higher total cerebral small vessel disease (CSVD) burden, as assessed by magnetic resonance imaging (MRI) markers, and with more pronounced cognitive decline in CSVD patients. However, the relationships among CSVD burden, cognitive impairment and WM changes remain unclear. We aimed to characterize WM microstructural abnormalities in patients with different CSVD burdens and investigate the mechanism linking different CSVD burdens to cognitive decline.This study included 56 patients with severe CSVD burden (CSVD-s), 109 patients with mild CSVD burden (CSVD-m) and 81 healthy controls. We used diffusion tensor imaging (DTI) and tract-based spatial statistics to detect WM diffusion changes between groups and then explored the relationships between different CSVD burdens, WM diffusion changes and cognitive function, especially to quantitatively analyze the possible mediating effect of WM microstructural alterations on CSVD burden and cognitive function.The CSVD-s group presented significantly decreased FA and increased AD, RD and MD in the forceps minor, bilateral anterior thalamic radiation (ATR), superior longitudinal fasciculus (SLF), corticospinal tract (CST) and inferior fronto-occipital fasciculus (IFOF). The simple mediation model revealed that the mean MD value of forceps minor and right IFOF, the mean FA value of the left CST and right IFOF, and the mean RD value of the left CST, SLF and right IFOF partially mediated the correlations between the CSVD burden and multiple cognitive scores.Our findings offer potential neuroimaging targets for intervening in and improving cognitive dysfunction in patients with different CSVD burdens.Copyright © 2025. Published by Elsevier Inc.

基金：
This work was supported by grants from Sichuan Provincial Joint Fund for Science and Technology Education General Project (2025NSFSC0259), the National Natural Science Foundation of China (32100902, 82272072), Research and Development Program Projects of North Sichuan Medical College (CBY25-QDA08), the Natural Science Foundation of Shandong Province (ZR2020MH288, ZR2024MH026), the Technology Development Plan of Jinan (202328066), the Medical and Health Science and Technology Development Project of Shandong Province (202309010557, 202309010560, 202409010479), the Shandong Province Medical System Employee Science and Technology Innovation Plan (SDYWZGKCIH2023034, SDYWZGKCJH2024021), and the Funding for Study Abroad Program by Shandong Province).
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外文
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中科院(CAS)分区：
出版当年[2025]版：
大类 | 2 区 医学
小类 | 2 区 神经科学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 神经科学
JCR分区：
出版当年[2023]版：
Q1 NEUROSCIENCES
最新[2024]版：
Q1 NEUROSCIENCES

影响因子： 最新[2024版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版] 出版后一年[2024版]

第一作者：
第一作者机构： [1]Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Agingei, Ministry of Education, Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jing-wu Road, Jinan 250021, China [2]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Sui Chaofan,Liang Changhu,Gao Yian,et al.The mediation effects of white matter microstructural abnormalities on the associations between cerebral small vessel disease burden and cognitive impairment[J].NEUROBIOLOGY OF DISEASE.2025,214:doi:10.1016/j.nbd.2025.107025.
APA：
Sui Chaofan,Liang Changhu,Gao Yian,Wang Na,Zhang Xinyue...&Wen Hongwei.(2025).The mediation effects of white matter microstructural abnormalities on the associations between cerebral small vessel disease burden and cognitive impairment.NEUROBIOLOGY OF DISEASE,214,
MLA：
Sui Chaofan,et al."The mediation effects of white matter microstructural abnormalities on the associations between cerebral small vessel disease burden and cognitive impairment".NEUROBIOLOGY OF DISEASE 214.(2025)

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