Disrupted Brain Structure-Function Coupling and Its Mediating Effects on the Associations Between Cerebral Small Vessel Disease Burden and Cognitive Dysfunction
机构：[1]Shandong First Med Univ, Dept Radiol, Key Lab Endocrine Glucose & Lipids Metab & Brain, Minist Educ,Shandong Prov Hosp, Jinan, Shandong, Peoples R China[2]Chinese Acad Med Sci & Peking Union Med Coll, China Japan Friendship Hosp, Inst Clin Med Sci, Dept Radiol, Beijing, Peoples R China[3]Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing, Peoples R China医技科室放射科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[4]Binzhou Med Univ, Yantai, Shandong, Peoples R China[5]Sichuan Univ, West China Hosp, Dept Med Ultrasound, Chengdu, Sichuan, Peoples R China四川大学华西医院[6]Shandong First Med Univ, Shandong Prov Hosp, Dept Med Genet, Jinan, Shandong, Peoples R China[7]Shandong First Med Univ, Shandong Prov Hosp, Prenatal Diag Ctr, Jinan, Shandong, Peoples R China[8]North Sichuan Med Coll, Sch Med Imaging, Nanchong, Sichuan, Peoples R China
Aims We aimed to specify relationships among cerebral small vessel disease (CSVD) burden, cognitive dysfunction, and brain structure-function coupling changes.Methods A total of 108 patients with mild CSVD burden (CSVD-m), 53 patients with severe CSVD burden (CSVD-s), and 76 healthy controls (HC) were included in this study. The ratio of regional homogeneity (ReHo) or amplitude of low-frequency fluctuation (ALFF) to gray matter volume (GMV) was calculated as an indicator of voxel-wise structure-function coupling.Results Significantly decreased or increased ReHo-GMV and ALFF-GMV coupling values in patients with severe CSVD burden were primarily found in several brain regions, and the disrupted structure-function coupling in the right putamen mediated the relationship between CSVD burden and cognitive dysfunction.Conclusions Brain structure-function coupling characterized by ReHo-GMV and ALFF-GMV mediated the cognitive dysfunction caused by CSVD and was an innovative and effective brain imaging indicator for exploring the association between CSVD burden and cognitive dysfunction.
基金：
the Sichuan Science and Technology Program (2025NSFSC2149), the Natural Science Foundation
of Shandong Province (ZR2020MH288, ZR2024MH026), the Research and Development Program Projects of North Sichuan Medical College (CBY25-
QDA08), the Technology Development Plan of Jinan (201301049, 201602206, 201907052, and 202328066), the Medical and Health Science and Technology
Development Project of Shandong Province (2016WS0529, 202309010557, 202309010560, 202409010479), the Funding for Study Abroad Program by
Shandong Province (201803059), the Shandong Province Medical System Employee Science and Technology Innovation Plan (SDYWZGKCIH2023034,
SDYWZGKCJH2024021).
第一作者机构：[1]Shandong First Med Univ, Dept Radiol, Key Lab Endocrine Glucose & Lipids Metab & Brain, Minist Educ,Shandong Prov Hosp, Jinan, Shandong, Peoples R China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Na,Guo Lingfei,Gao Yian,et al.Disrupted Brain Structure-Function Coupling and Its Mediating Effects on the Associations Between Cerebral Small Vessel Disease Burden and Cognitive Dysfunction[J].CNS NEUROSCIENCE & THERAPEUTICS.2025,31(9):doi:10.1111/cns.70604.
APA：
Wang, Na,Guo, Lingfei,Gao, Yian,Sui, Chaofan,Zhang, Xinyue...&Wen, Hongwei.(2025).Disrupted Brain Structure-Function Coupling and Its Mediating Effects on the Associations Between Cerebral Small Vessel Disease Burden and Cognitive Dysfunction.CNS NEUROSCIENCE & THERAPEUTICS,31,(9)
MLA：
Wang, Na,et al."Disrupted Brain Structure-Function Coupling and Its Mediating Effects on the Associations Between Cerebral Small Vessel Disease Burden and Cognitive Dysfunction".CNS NEUROSCIENCE & THERAPEUTICS 31..9(2025)
