详情页 - 首都医科大学附属北京同仁医院知识库

当前位置：首页 > 详情页

Folate-guided AIE nanoparticles integrate macrophage-targeted fluorescence imaging and photodynamic immunomodulation in rheumatoid arthritis

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan 430070, PR China [2]Tongren Hospital Affiliated to Wuhan University, Wuhan 430000, PR China [3]Wuhan Sports University, Wuhan 430079, PR China

出处：

DOI：

ISSN：

关键词： Rheumatoid arthritis Aggregation-induced emission (AIE) Singlet oxygen (1O2) Fluorescence imaging Immunomodulation

摘要：

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and macrophage-driven immune dysregulation. Here, we developed a multifunctional nanoplatform (FA@4BC NPs) by encapsulating an AIE-active curcumin-derived photosensitizer (4BC) within folate-functionalized PEGylated liposomes. The system enables precise targeting of activated macrophages through folate receptor-β (FR-β) recognition, and upon laser irradiation, efficiently generates singlet oxygen (1O2), promoting M1-to-M2 macrophage polarization and initiating anti-inflammatory signaling pathways. In a collagen-induced arthritis (CIA) mouse model, FA@4BC NPs selectively accumulated in inflamed joints, enabling high-contrast in vivo fluorescence imaging. Histological and immunohistochemical analyses further demonstrated that this nanoplatform effectively improved synovial architecture, reduced inflammatory cell infiltration, and alleviated cartilage damage, exhibiting desirable anti-inflammatory and bone-protective effects. This study demonstrates a non-cytotoxic photodynamic therapy strategy based on natural product, integrating targeted imaging, immune modulation, and joint repair, offering a promising paradigm for precision RA therapy.Copyright © 2025 Elsevier B.V. All rights reserved.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2025]版：

大类 | 2 区医学

小类 | 1 区生物物理 3 区材料科学：生物材料

最新[2025]版：

大类 | 2 区医学

小类 | 1 区生物物理 3 区材料科学：生物材料

第一作者：

第一作者机构： [1]State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan 430070, PR China

共同第一作者：

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Association of Long-Term Exposure to PM2.5 Constituents and Green Space With Arthritis and Rheumatoid Arthritis [2]Overlapping genes connect rheumatoid arthritis and head and neck cancer: coincidence or shared immune pathophysiology? [3]MiR-326 regulates cell proliferation and apoptosis in fibroblast-like synoviocytes in rheumatoid arthritis [4]Identification and Development of Synovial B-Cell-Related Genes Diagnostic Signature for Rheumatoid Arthritis [5]METTL14-mediated m6A modification of TNFAIP3 involved in inflammation in patients with active rheumatoid arthritis [6]类风湿关节炎合并支气管扩张临床及危险因素分析 [7]类风湿性关节炎所致角膜边缘溶解症 [8]类风湿性关节炎患者腰椎手术的影响因素分析 [9]辅助性T细胞9在类风湿关节炎发病中的作用探讨 [10]Mst1 promotes mitochondrial dysfunction and apoptosis in oxidative stress-induced rheumatoid arthritis synoviocytes