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Consensuses and controversies on causes, diagnosis and management of diabetic macular edema (DME)

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资源类型：
Pubmed体系：
作者：
Ng Danny S C[1,2] * ; Ruamviboonsuk Paisan[3] ; Apte Rajendra S[4,5,6] ; Bajimaya Sanyam[7] ; Chan Carmen K M[2,8] ; Chang Andrew[9] ; Cheung Carol Y[2] ; Chen Shih-Jen[10] ; Chaudhary Varun[11] ; Chaikitmongkol Voraporn[12] ; Chhablani Jay[13] ; Das Taraprasad[14,15] ; Huang Suber S[16,17,18] ; Jonas Jost B[14,19,20,21,22] ; Lai Timothy Y Y[2] ; Lai Chi-Chun[23,24] ; Ma Jin[25] ; Munk Marion R[26,27,28] ; Narayanan Raja[14,29] ; Radke Nishant V[1,30,31] ; Sagong Min[32] ; Sabanayagam Charumathi[20,33] ; Sivaprasad Sobha[34,35] ; Shimura Masahiko[36] ; Sonoda Koh-Hei[37] ; Sun Jennifer K[38,39] ; Tan Gavin S W[20,33] ; Takkar Brijesh[14] ; Virgili Gianni[40,41,42] ; Vujosevic Stela[43,44] ; Wang Min[45,46] ; Yu Seung-Young[47] ; Zhang Xinyuan[48,49] ; Zhang Jingfa[1,30,31] ; Wong Tien-Yin[20,50,51,52] ; Lam Dennis S C[1,2,30,31,53] ;
机构： [1]The Primasia International Eye Research Institute (PIERI) of The Chinese University of Hong Kong (Shenzhen), Shenzhen, China [2]Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China [3]Department of Ophthalmology, College of Medicine, Rangsit University, Rajavithi Hospital, Bangkok, Thailand [4]John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine in St. Louis, St. Louis, Missouri, US [5]Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, US [6]Department of Developmental Biology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, US [7]Tilganga Institute of Ophthalmology, Kathmandu, Nepal [8]Hong Kong Eye Hospital, Hong Kong, China [9]Sydney Retina Clinic, Sydney Eye Hospital, University of Sydney, Sydney, NSW, Australia [10]Department of Ophthalmology, Taipei Veterans General Hospital, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan [11]Department of Surgery, Hamilton Regional Eye Institute, McMaster University, Hamilton, Ontario, Canada [12]Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand [13]Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, US [14]LV Prasad Eye Institute, Kalam Anji Reddy Campus, Anant Bajaj Retina Institute, Srimati Kanuri Santhamma Centre for Vitreoretinal Diseases, Hyderabad, India [15]Shantilal Shanghvi Eye Institute, Mumbai, India [16]Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore [17]Retina Center of Ohio, Cleveland, OH, US [18]Bascom Palmer Eye Institute, University of Miami, Coral Gables, FL, US [19]Rothschild Foundation Hospital, Institut Français de Myopie, Paris, France [20]Singapore Eye Research Institute, Singapore National Eye Center, Singapore [21]Privatpraxis Prof Jonas und Dr. Panda-Jonas, Heidelberg, Germany [22]Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China [23]Department of Ophthalmology, New Taipei Municipal TuCheng Hospital, New Taipei City, Taiwan [24]College of Medicine, Chang Gung University, Taoyuan, Taiwan [25]State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Provincial Clinical Research Center for Ocular Diseases, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China [26]Department of Ophthalmology, Bern University Hospital, University of Bern, Bern, Switzerland [27]Gutblick Practise Group, Pfäffikon, Switzerland [28]Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, US [29]Indian Health Outcomes, Public Health and Economics Research Center (IHOPE), LV Prasad Eye Institute, Hyderabad, India [30]The C-MER (Shenzhen) Dennis Lam Eye Hospital, Shenzhen, China [31]Eye Department, C+ Health CKJ (Shenzhen) Hospital, Luohu, Shenzhen, China [32]Department of Ophthalmology, Yeungnam University College of Medicine, Yeungnam University Hospital, Daegu, Korea [33]Ophthalmology and Visual Science Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore [34]Institute of Ophthalmology, University College London, London, UK [35]National Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital National Health Service Foundation Trust, London, UK [36]Department of Ophthalmology, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan [37]Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan [38]Beetham Eye Institute, Joslin Diabetes Center, Boston, MA, US [39]Department of Ophthalmology, Harvard Medical School, Boston, MA, US [40]Eye Clinic, Department of Neuromuscular Diseases and Sense Organs, Careggi University Hospital, Florence, Italy [41]Department of Neuroscience, Psychology, Pharmacology and Pediatrics (Neurofarba), University of Florence, Florence, Italy [42]IRCCS-Fondazione Bietti, Rome, Italy [43]Department of Biomedical Surgical and Dental Sciences, University of Milan, Milan, Italy [44]Eye Clinic, IRCCS MultiMedica, Milan, Italy [45]Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China [46]Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China [47]Department of Ophthalmology, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea [48]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China [49]Beijing Retinal and Choroidal Vascular Diseases Study Group, Beijing Tongren Hospital, Beijing, China [50]Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital Eye Center, Tsinghua Medicine, Tsinghua University, Beijing, China [51]School of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China [52]Beijing Key Laboratory of Intelligent Diagnostic Technology and Devices for Major Blinding Eye Diseases, Tsinghua Medicine, Tsinghua University, Beijing, China [53]The C-MER Dennis Lam and Partners Eye Center, C-MER International Eye Care Group, Hong Kong, China
出处：
DOI： 10.1016/j.preteyeres.2025.101406
ISSN：

关键词： diabetic macular edema consensus controversy causes diagnosis and management

摘要：
Diabetic macular edema (DME) is the most common cause of vision-threatening diabetic retinopathy (VTDR) with an increasing prevalence tied to the global epidemic in diabetes. Despite significant advances, the management of DME remains a dynamic field with many unresolved controversies. Optical coherence tomography (OCT) allows objective assessment, however, correlation between vision and morphological changes can be inconsistent, causing disagreements on treatment strategies. DME is a complex disease with multifactorial pathophysiological pathways, leading to heterogenous treatment responses. There is a lack of standardized definition of treatment 'non-response" and protocol for switching to second-line or adjuvant treatments. New anti-vascular endothelial growth factor (anti-VEGF) drugs and multi-targeted therapies seem to demonstrate improved durability, but long-term data is not yet available. Research in artificial intelligence (AI) is developing rapidly, however, rigorous appraisal of its reliability and generalizability are necessary before its implementation. Significant vision loss from DME in pregnant women, young children and elderly patients with systemic comorbidities are challenging conundrums. An international panel of experts (IPE) comprising 36 experts from 16 countries formulated and voted on the consensus statements in 5 key areas: 1) Diagnostic controversies around classification and imaging; 2) Treatment controversies; 3) Management paradigm between protocol-based and individualized approaches; 4) Emerging controversies in novel therapeutics and AI application, and 5) Special considerations for specific patient populations. There is an imminent need for mutual agreement on the best-possible approach to DME management in order to promote the optimal patient outcomes and to identify specific issues that require prioritization of resources and research.Copyright © 2025. Published by Elsevier Ltd.

基金：
Ms. May Lam Research and Education Fund of The Primasia International Eye Research Institute (PIERI) of The Chinese University of Hong Kong (Shenzhen); Shun Hing Education and Charity Fund; Bright Future Charitable Foundation Postgraduate Education Fund; Daniel & Co Scholarship
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 1 区 医学
小类 | 1 区 眼科学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 眼科学
第一作者：
第一作者机构： [1]The Primasia International Eye Research Institute (PIERI) of The Chinese University of Hong Kong (Shenzhen), Shenzhen, China [2]Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
通讯作者：
通讯机构： [1]The Primasia International Eye Research Institute (PIERI) of The Chinese University of Hong Kong (Shenzhen), Shenzhen, China [2]Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China [20]Singapore Eye Research Institute, Singapore National Eye Center, Singapore [30]The C-MER (Shenzhen) Dennis Lam Eye Hospital, Shenzhen, China [31]Eye Department, C+ Health CKJ (Shenzhen) Hospital, Luohu, Shenzhen, China [50]Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital Eye Center, Tsinghua Medicine, Tsinghua University, Beijing, China [51]School of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China [52]Beijing Key Laboratory of Intelligent Diagnostic Technology and Devices for Major Blinding Eye Diseases, Tsinghua Medicine, Tsinghua University, Beijing, China [53]The C-MER Dennis Lam and Partners Eye Center, C-MER International Eye Care Group, Hong Kong, China
推荐引用方式(GB/T 7714)：
Ng Danny S C,Ruamviboonsuk Paisan,Apte Rajendra S,et al.Consensuses and controversies on causes, diagnosis and management of diabetic macular edema (DME)[J].Progress In Retinal And Eye Research.2025,101406.doi:10.1016/j.preteyeres.2025.101406.
APA：
Ng Danny S C,Ruamviboonsuk Paisan,Apte Rajendra S,Bajimaya Sanyam,Chan Carmen K M...&Lam Dennis S C.(2025).Consensuses and controversies on causes, diagnosis and management of diabetic macular edema (DME).Progress In Retinal And Eye Research,,
MLA：
Ng Danny S C,et al."Consensuses and controversies on causes, diagnosis and management of diabetic macular edema (DME)".Progress In Retinal And Eye Research .(2025):101406

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