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Novel combinatorial transdermal drug delivery of alendronate with risedronate for the treatment of osteoporosis

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收录情况： ◇ SCIE

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机构： [1]Department of Minimally Invasive Spine Surgery, Luoyang Orthopedic Hospital of Henan Province, Zhengzhou City, Henan, 450018, China [2]Integrated Orthopedic Department of Traditional Chinese Medicine (TCM) and Western Medicine Hong-Hui Hospital, Xi’an Jiaotong University College of Medicine, Xi’an City, Shaanxi, 710054, China [3]Deparment of Orthopedics, Beijing Tongren Hospital, Biejing, China [4]Department of Orthopedics, Shidong Hospital, Yangpu District, Shanghai, 200438, China

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关键词： alendronate risedronate PLGA nanoparticles transdermal patches osteoporosis

摘要：

The presented investigation explores the efficiency of novel transdermal drug delivery system of combination of two drugs i.e risedronate and alendronate in the treatment of osteoporosis. The nanoparticulate transdermal patch was prepared using PLGA as principle polymer which has been found to be suitable for drug delivery. The novel formulation system was found to be more efficient in lowering and maintaining the plasma calcium at a normal level when compared to a pure drug in a study carried out on an excised rat skin.

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出版当年[2018]版：

大类 | 4 区生物

小类 | 4 区生化与分子生物学

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学

JCR分区：

出版当年[2017]版：

Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2024]版：

Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 1.7 最新[2024版] 2 最新五年平均 1.239 出版当年[2017版] 1.541 出版当年五年平均 1.159 出版前一年[2016版] 1.626 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Minimally Invasive Spine Surgery, Luoyang Orthopedic Hospital of Henan Province, Zhengzhou City, Henan, 450018, China

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