机构：[1]Department of Military Hygiene, Faculty of Naval Medicine, Second Military Medical University, 800 Xiang Yin Road, Shanghai, China[2]Department of Nutrition, Tong Ren Hospital Affiliated to Shanghai JiaoTong University School of Medicine, 1111 Xian Xia Road, Shanghai, China
Low dose dexamethasone has been widely used for the prevention of nausea and vomiting after chemotherapy and surgical procedures and to treat motion sickness due to its minimal adverse effects, but the mechanisms underlying its anti-motion sickness effects are poorly understood. Previous studies have demonstrated that the endocannabinoid system is suppressed by motion sickness but stimulated by dexamethasone. The aim of the present study was to determine whether dexamethasone has an anti-motion sickness effect in rats and to elucidate the mechanism of this action. We used HPLC-MS/MS to measure the plasma concentrations of anandamide and 2-arachidonoylglycerol+1-arachidonoylglycerol, and we employed real-time quantitative PCR (qRT-PCR) and/or Western blot analysis to assay the expression of N-acylphosphaticlyl-ethanolamine hydrolyzing phospholipase D. sn-1-selective diacylglycerol lipase, fatty acid hydrolase, monoacylglycerol lipase and endocannabinoid CBI receptor in the dorsal vagal complex and stomach of rats exposed to a motion sickness protocol. The results showed that dexamethasone lowered the motion sickness index and restored the levels of endogenous cannabinoids and the expression of the endocannabinoid CB1 receptor, which declined after the induction of motion sickness, in the dorsal vagal complex and stomach. (C) 2014 Elsevier B.V. All rights reserved
基金：
Youth Grant of Second Millitary Medical University, China [2011QNO3]; Military Special Research Project of Traditional Chinese Medicine [10ZYZ130]; Shanghai Public Health funding for Construction of Key Disciplines
第一作者机构：[1]Department of Military Hygiene, Faculty of Naval Medicine, Second Military Medical University, 800 Xiang Yin Road, Shanghai, China[2]Department of Nutrition, Tong Ren Hospital Affiliated to Shanghai JiaoTong University School of Medicine, 1111 Xian Xia Road, Shanghai, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Military Hygiene, Faculty of Naval Medicine, Second Military Medical University, 800 Xiang Yin Road, Shanghai, China
推荐引用方式(GB/T 7714)：
Zheng Yan,Wang Xiao-Li,Mo Feng-Feng,et al.Dexamethasone alleviates motion sickness in rats in part by enhancing the endocannabinoid system[J].EUROPEAN JOURNAL OF PHARMACOLOGY.2014,727:99-105.doi:10.1016/j.ejphar.2014.01.047.
APA：
Zheng, Yan,Wang, Xiao-Li,Mo, Feng-Feng&Li, Min.(2014).Dexamethasone alleviates motion sickness in rats in part by enhancing the endocannabinoid system.EUROPEAN JOURNAL OF PHARMACOLOGY,727,
MLA：
Zheng, Yan,et al."Dexamethasone alleviates motion sickness in rats in part by enhancing the endocannabinoid system".EUROPEAN JOURNAL OF PHARMACOLOGY 727.(2014):99-105
