机构：[1]Department of Neurology, TongRen Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China[2]Department of Neurosurgery, Hamamatsu University School of Medicine, Handayama, 1-20-1, Higashi-ku, Hamamatsucity, Shizuoka 431-3192, Japan[3]Research Base of Traditional Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
Restless legs syndrome (RLS)/Willis-Ekbom disease is a neurologic disorder characterized by a strong desire to move when at rest (usually in the evening) and paraesthesia in their lower legs. The most widely used therapies for first-line treatment of RLS are dopaminergic drugs; however, their long-term use can lead to augmentation. a2d Ligands, opioids, iron, glutamatergic drugs, adenosine, and sleep aids have been investigated as alternatives. The pathogenesis of RLS is not well understood. Despite the efficacy of dopaminergic drugs in the treatment of this disorder, unlike in Parkinson's disease dopaminergic cell loss in the substantia nigra has not been observed in RLS. The etiology of RLS is likely complex, involving multiple neural pathways. RLS-related genes identified in genome-wide association studies can provide insight into the mechanistic basis and pathophysiology of RLS. Here we review the current treatments and knowledge of the mechanisms underlying RLS.
基金：
National Natural Science Foundation of China (NSFC) [81671103]
第一作者机构：[1]Department of Neurology, TongRen Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China
通讯作者：
通讯机构：[1]Department of Neurology, TongRen Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China[2]Department of Neurosurgery, Hamamatsu University School of Medicine, Handayama, 1-20-1, Higashi-ku, Hamamatsucity, Shizuoka 431-3192, Japan[3]Research Base of Traditional Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China[*1]Department of Neurology, TongRen Hospital, Shanghai Jiao Tong University School of Medicine, No.1111 Xianxia Road, 200336, Shanghai, China[*2]Department of Neurosurgery, Hamamatsu University School of Medicine, Handayama, 1-20-1, Higashi-ku, Hamamatsu-city, Shizuoka 431-3192, Japan
推荐引用方式(GB/T 7714)：
Lv Qing,Wang Xinlin,Asakawa Tetsuya,et al.Pharmacologic Treatment of Restless Legs Syndrome[J].CURRENT NEUROPHARMACOLOGY.2021,19(3):372-382.doi:10.2174/1570159X19666201230150127.
APA：
Lv, Qing,Wang, Xinlin,Asakawa, Tetsuya&Wang, Xiao Ping.(2021).Pharmacologic Treatment of Restless Legs Syndrome.CURRENT NEUROPHARMACOLOGY,19,(3)
MLA：
Lv, Qing,et al."Pharmacologic Treatment of Restless Legs Syndrome".CURRENT NEUROPHARMACOLOGY 19..3(2021):372-382
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