机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany[3]Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland[4]Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany[5]Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China首都医科大学附属北京同仁医院临床科室眼科眼底科[6]Eye Center, the 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China[7]Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany
Purpose Previous studies have shown that the retinal nerve fibre layer (RNFL) thickness as surrogate of the optic nerve decreases with longer axial length. We explored which explanatory parameters might explain that association. Methods Participants of the population-based Beijing Eye Study 2011 without any retinal or optic nerve disease were selected based on a refractive error-based stratified randomization. Results The study included of 632 participants (age: 59.1 +/- 7.3 years; axial length: 23.5 +/- 1.2 mm; range: 20.88-28.68 mm). Thicker RNFL (mean: 101.0 +/- 10.0 mu m) was associated (multivariable analysis) with smaller parapapillary gamma zone (defined as Bruch's membrane-free parapapillary region) (standardized regression coefficient beta: -0.13; non-stadardized regression coefficient B: -0.008; 95% confidence interval (CI): -0.014, -0.003; p = 0.005) and shorter disc-fovea distance (beta: -0.15; B: -3.91; 95% CI: -6.60; -1.22; p = 0.004), after adjusting for age (beta: -0.22; B: -030; 95% CI: -0.41, -0.19; p < 0.001), gender (beta: 0.12; B: 2.37; 95% CI 0.77, 3.97; p = 0.004) and larger optic disc area (beta: 0.12; B: 0.12; 95% CI: 2.14; 95% CI: 0.54, 3.73; p = 0.009). RNFL thickness decreased by 8 mu m (95% CI: 3, 14) for each mm increase in gamma zone width, and by 3.91 mu m (95% CI: 1.22, 6.60) for each mm elongation of the disc-fovea distance. If disc-fovea distance and gamma zone width were replaced by axial length, the latter was correlated with RNFL thickness (beta: -0.37; B: -3.12; 95% CI: -3.88, -2.35; p < 0.001). Longer disc-fovea distance was directly associated with larger gamma zone (beta: 0.50; B: p < 0.001). Conclusions The RNFL thickness decrease with longer axial length is associated with a longer optic disc-fovea distance and larger parapapillary gamma zone. Longer disc-fovea distance and larger gamma zone lead to an elongation and stretching of the retinal nerve fibres, potentially causing a thinning or loss of the nerve fibres. It may explain the occurrence of visual field defects in some non-glaucomatous highly myopic eyes without macular correlates of the perimetric defects.
基金：
National Natural Science Foundation of China (#81570835); Beijing Municipal of Health Reform and Development Project (#2019-4)
第一作者机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China[2]Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany[3]Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland[4]Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany
共同第一作者：
通讯作者：
通讯机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China[*1]Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital Capital University of Medical Science 1 Dongjiaomin Lane Dongcheng District Beijing 100730, China
推荐引用方式(GB/T 7714)：
Jonas Jost B.,Yan Yan Ni,Zhang Qi,et al.Retinal nerve fibre layer thickness in association with gamma zone width and disc-fovea distance[J].ACTA OPHTHALMOLOGICA.2022,100(6):632-639.doi:10.1111/aos.15088.
APA：
Jonas, Jost B.,Yan, Yan Ni,Zhang, Qi,Zhang, Qing,Wei, Wen Bin...&Wang, Ya Xing.(2022).Retinal nerve fibre layer thickness in association with gamma zone width and disc-fovea distance.ACTA OPHTHALMOLOGICA,100,(6)
MLA：
Jonas, Jost B.,et al."Retinal nerve fibre layer thickness in association with gamma zone width and disc-fovea distance".ACTA OPHTHALMOLOGICA 100..6(2022):632-639
