AIM: To report the progression rate (PR) to primary angle closure (PAC) following laser peripheral iridotomy (LPI) in PAC suspects (PACS). METHODS: Prospective, randomized controlled interventional clinical trial conducted at the Handan Eye Hospital, China. Totally 134 bilateral PACS, defined as non-visibility of the posterior trabecular meshwork for >= 180 degrees on gonioscopy were randomly assigned to undergo LPI in one eye. Gonioscopy and Goldmann applanation tonometry were performed prior to, on day 7 and 12mo post LPI. RESULTS: Eighty of 134 patients (59.7%) could be followed up at one year. The mean intraocular pressure (IOP) in treated eyes was 15.9 +/- 2.6 mm Hg at baseline, 15.4 +/- 3.0 mm Hg on day 7; 16.5 +/- 2.9 mm Hg at one month, and 15.5 +/- 2.9 mm Hg at 12mo; the IOP in untreated eyes was similar (P=0.834). One or more quadrants of the angle opened in 93.7% of the LPI treated eyes, but 67.0% (53/79) remained closed in two or more quadrants. The PR to PAC in untreated eyes was 3.75% and one developed acute angle-closure glaucoma (AACG); the PR to PAC in treated eyes was 2.5% and none had developed peripheral anterior synechia (PAS) or AACG. CONCLUSION: LPI can open some of the occludable angle in the majority of eyes with PACS, but 67% continue to have non-visibility of the trabecular meshwork for over 180 degrees.
基金：
Ministry of Science and Technology of the National "Eleventh Five-Year" Science and Technology Program in China [2007BAI1 8B08]; Beijijng Municipal Science and Technology Commission, Capital Characteristic Clinic Project [Z171100001017040]
第一作者机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University. Beijing Ophthalmology&Visual Science Key Lab, Beijing 100730, China
通讯作者：
通讯机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University. Beijing Ophthalmology&Visual Science Key Lab, Beijing 100730, China[*1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University. Beijing Ophthalmology & Visual Science Key Lab, No.l. Dong Jiao Min Xiang, Beijing 100730, China,
推荐引用方式(GB/T 7714)：
Mou Da-Peng,Liang Yuan-Bo,Fan Su-Jie,et al.Progression rate to primary angle closure following laser peripheral iridotomy in primary angle-closure suspects: a randomised study[J].INTERNATIONAL JOURNAL OF OPHTHALMOLOGY.2021,14(8):1179-1184.doi:10.18240/ijo.2021.08.07.
APA：
Mou, Da-Peng,Liang, Yuan-Bo,Fan, Su-Jie,Peng, Yi,Wang, Ning-Li&Thomas, Ravi.(2021).Progression rate to primary angle closure following laser peripheral iridotomy in primary angle-closure suspects: a randomised study.INTERNATIONAL JOURNAL OF OPHTHALMOLOGY,14,(8)
MLA：
Mou, Da-Peng,et al."Progression rate to primary angle closure following laser peripheral iridotomy in primary angle-closure suspects: a randomised study".INTERNATIONAL JOURNAL OF OPHTHALMOLOGY 14..8(2021):1179-1184
