机构：[1]Division of Rhinology, Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan[2]Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taiwan[3]Department of Otolaryngology, Xiamen Chang Gung Hospital, Xiamen, China[4]Department of Otolaryngology–Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Keelung, Taiwan[5]Department of Thoracic Medicine, Chang Gung Memorial Hospital and Medicine of College, Chang Gung University, Taoyuan, Taiwan
Background: Cigarette smoke have adverse effects in the control of asthma and chronic rhinosinusitis (CRS). Interleukin (IL)-17A, the signature cytokine of helper T 17 cells and group 3 innate lymphoid cells (ILC3), has been reported to link with resistance to therapy in airway inflammation. This study aimed to investigate the impact of cigarette smoking and IL-17A activation on the clinical outcomes of asthmatic patients with chronic rhinosinusitis.
Methods: 33 patients with CRS and asthma, including 15 smokers and 18 non-smokers, and 7 asthmatic patients without CRS and smoking were prospectively recruited. The Sino-Nasal Outcome Test-22 and Asthma Control Test were used to evaluate sinonasal symptoms and the level of asthma control, respectively. Real-time PCR and immunostaining were applied to evaluate the expression levels of IL-17A and associated immunological factors on surgically-obtained nasal tissues.
Results: Nasal surgery improved both sinonasal symptoms and asthma control. Compared to non-smokers, smokers showed poorer improvement in asthma control. The expression of IL-17A, IL-22, aryl hydrocarbon receptor (AhR), and ILC3 was increased in the nasal tissues of smokers with asthma and CRS. The expression of IL-17A mRNA was correlated with that of AhR and with positive nuclear AhR-AhR nuclear translocator staining cells, and that of cyclooxygenase-2 enzyme (COX-2). ILC3 cells were associated with IL-17A, IL-22, AhR, and COX-2 mRNA expression.
Conclusions: Cigarette smoking was related to lesser improvement in asthma control after nasal surgery and to IL-17A activation in the nasal tissues of patients with inflammatory airways.
基金：
Chang Gung
Memorial Hospital (CMRPG3D0831, CMRPG3G0671, and CMRPG3G0061).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区医学
小类|2 区耳鼻喉科学
最新[2023]版：
大类|2 区医学
小类|1 区耳鼻喉科学
第一作者：
第一作者机构：[1]Division of Rhinology, Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan[2]Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taiwan
共同第一作者：
通讯作者：
通讯机构：[5]Department of Thoracic Medicine, Chang Gung Memorial Hospital and Medicine of College, Chang Gung University, Taoyuan, Taiwan[*1]Department of Thoracic Medicine Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan No. 5, Fu-Shin Street, Kweishan Taoyuan 333, Taiwan
推荐引用方式(GB/T 7714)：
Chien-Chia Huang,Ta-Jen Lee,Chi-Che Huang,et al.Impact of cigarette smoke and IL-17A activation on asthmatic patients with chronic rhinosinusitis[J].Rhinology.2019,57(1):57-66.doi:10.4193/Rhin18.131.
APA：
Chien-Chia Huang,Ta-Jen Lee,Chi-Che Huang,Po-Hung Chang,Chia-Hsiang Fu...&Chun-Hua Wang.(2019).Impact of cigarette smoke and IL-17A activation on asthmatic patients with chronic rhinosinusitis.Rhinology,57,(1)
MLA：
Chien-Chia Huang,et al."Impact of cigarette smoke and IL-17A activation on asthmatic patients with chronic rhinosinusitis".Rhinology 57..1(2019):57-66
