机构：[1]Department of Radiology, Changzheng Hospital, Second Military Medical University, Shanghai, China[2]Hongqiao Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiaotong University School of Medicine, Shanghai, China[3]Department of Thoracic Surgery, Lanling People's Hospital, Lanling County, Linyi, China[4]Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry & Molecular Cellular Biology, Shanghai Jiaotong University School of Medicine, Shanghai, China
Snail is a prominent epithelial-mesenchymal transition (EMT) transcription factor and promotes metastasis. However, Snail protein is unstable and is quickly degraded through ubiquitination-mediated proteasome pathway. Deubiquitinases prevent Snail degradation by regulating the ubiquitination-mediated hydrolysis process. Our studies demonstrate that a deubiquitinating enzyme (DUB) family member, USP37, can deubiquitinate Snail and prevent degradation of Snail. USP37 is co-localized with Snail in the nucleus. Biologically, upregulated expression of USP37 promotes lung cancer cell migration, while depletion of Snail abolishes the effect of USP37. These data demonstrate that USP37 is a Snail-specific deubiquitinase and also indicate a potential therapeutic target for metastasis.
基金：
National Key
Research and Development Program of China for
Intergovernmental Cooperation (2016YFE0103000), the
National Science Foundation of China (grant no. 81230030;
no. 31601114; no. 31970679), and National Program on Key
Basic Research Project (973 Program, 2015CB931803) and
Sponsored by Shanghai Rising-Star Program (19QA1405000),
and Shanghai Talent Development Funding for the project
(grant No. 2017034).
第一作者机构：[1]Department of Radiology, Changzheng Hospital, Second Military Medical University, Shanghai, China
共同第一作者：
通讯作者：
通讯机构：[2]Hongqiao Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiaotong University School of Medicine, Shanghai, China[4]Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry & Molecular Cellular Biology, Shanghai Jiaotong University School of Medicine, Shanghai, China
推荐引用方式(GB/T 7714)：
Cai Jiali,Li Mengying,Wang Xiang,et al.USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination[J].FRONTIERS IN GENETICS.2020,10:doi:10.3389/fgene.2019.01324.
APA：
Cai, Jiali,Li, Mengying,Wang, Xiang,Li, Lei,Li, Qi...&Liu, Shiyuan.(2020).USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination.FRONTIERS IN GENETICS,10,
MLA：
Cai, Jiali,et al."USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination".FRONTIERS IN GENETICS 10.(2020)
