机构：[1]Department of Forensic Science, School of Basic Medical Science, Central South University, Changsha, China.[2]Department of Histology and Embryology, School of Basic Medical Science, Central South University, Changsha, China.[3]Department of Medical Records Statistics, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, China.[4]Department of Cardiovascular Medicine, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, China.
Multiorgan injury has been implicated in patients with coronavirus disease 2019 (COVID-19). We aim to assess the impact of organ injury (OI) on prognosis according to the number of affected organs at admission.This is a retrospective cohort study of patients with confirmed COVID-19 in Wuhan Third Hospital & Tongren Hospital of Wuhan University from February 17 to March 22, 2020. We classified the patients according to the presence and number of damaged organs (heart, liver, and kidney).The percentage of patients with no, one, two, or three organs affected was 59.75%, 30.46%, 8.07%, and 1.72%, respectively. With the increasing number of OI, there is a tendency of gradual increase regarding the white blood cell counts, neutrophil counts, levels of C-reactive protein, lactate dehydrogenase, D-dimer, and fibrinogen as well as the incidence of most complications. In a Cox regression model, individuals with OI, old age, and an abnormal level of C-reactive protein were at a higher risk of death compared with those without. Patients with three organ injuries had the highest mortality rate [57.9%; hazard ratio (HR) with 95% confidence interval (CI) vs. patients without OI: 22.31 (10.42-47.77), those with two (23.6%; HR 8.68, 95% CI 4.58-16.48), one (8.6%; HR 3.1, 95% CI 1.7-5.7), or no OI (2.6%); P < 0.001].The increasing number of OI was associated with a high risk of mortality in COVID-19 infection. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.
基金：
National Natural Science Foundation of China,
Grant/Award Numbers: 81772024, 81871088;
Hubei Province Health and Family Planning
Scientific Research Project,
Grant/Award Number: WJ2019M006; Wuhan
Municipal Population and Family Planning
Commission Foundation,
Grant/Award Number: WX16C03; Hubei
Province Natural Science Fund,
Grant/Award Number: 2020CFB660; Applied
Basic Research Program of Wuhan Municipal
Bureau of Science and Technology,
Grant/Award Number: 2019020701011473
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|4 区医学
小类|4 区病毒学
最新[2025]版：
大类|3 区医学
小类|3 区病毒学
第一作者：
第一作者机构：[1]Department of Forensic Science, School of Basic Medical Science, Central South University, Changsha, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Forensic Science, School of Basic Medical Science, Central South University, Changsha, China.[4]Department of Cardiovascular Medicine, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, China.[*1]Department of Cardiovascular Medicine, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, 430074, Hubei, China[*2]Department of Forensic Science, School of Basic Medical Science, Central South University, Changsha, 410013, Hunan, China.
推荐引用方式(GB/T 7714)：
Yan He,Lu Shanshan,Chen Liangpei,et al.Multiple Organ Injury on Admission Predicts In-Hospital Mortality in Patients with COVID -19.[J].Journal Of Medical Virology.2020,doi:10.1002/jmv.26534.
APA：
Yan He,Lu Shanshan,Chen Liangpei,Wang Yufang,Liu Qiaomei...&Yan Jie.(2020).Multiple Organ Injury on Admission Predicts In-Hospital Mortality in Patients with COVID -19..Journal Of Medical Virology,,
MLA：
Yan He,et al."Multiple Organ Injury on Admission Predicts In-Hospital Mortality in Patients with COVID -19.".Journal Of Medical Virology .(2020)
