机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL 33136, USA[3]Research institute of Ophthalmology, Giza 12557, Egypt[4]Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Eye Institute, Beijing 100730, China首都医科大学附属北京同仁医院研究所眼科研究所[5]Department of Neurology and Medical Research Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China临床科室神经内科首都医科大学附属北京同仁医院首都医科大学附属同仁医院
The present study aims to investigate the effect of temporary cerebrospinal fluid pressure (CSFP) reduction on optic nerve head (ONH) and macular vessel density (VD) using optical coherence tomography angiography. Forty-four eyes of 44 adults with diagnostic lumbar puncture and CSFP reduction were recruited. Thirty-two eyes of 32 healthy volunteers were controls. ONH and macular VD images were evaluated differences between baseline and after CSFP reduction. The results showed that the mean CSFP decreased from (11.6 +/- 2.1) mmHg to (8.2 +/- 3.4) mmHg (P<0.001). VD in the macular regions decreased significantly after CSFP reduction in the study group (all P<0.05). The control group showed no significant changes in macular VD (all P>0.05). In the study group, decreased VD in the macular parainferior region was associated with CSFP reduction (R-2=0.192, P=0.003), the reduction of macular VD in parafoveal (R-2=0.098, P=0.018), parainferior (R-2=0.104, P=0.021), parasuperior (R-2=0.059, P=0.058), paranasal (R-2=0.057, P=0.042), paratemporal (R-2=0.079, P=0.026) was associated with mean ocular perfusion pressure decrease following CSFP reduction. ONH vessel density did not differ after CSFP reduction (all P>0.05). In conclusion, macular vessel density decreased in association with CSFP reduction. Retinal vessel density in the macular region is more sensitive than that in peripapillary region after CSFP reduction.
第一作者机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China[2]Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL 33136, USA[4]Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Eye Institute, Beijing 100730, China
通讯作者：
通讯机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China[4]Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Eye Institute, Beijing 100730, China
推荐引用方式(GB/T 7714)：
Liu Xiangxiang,Khodeiry Mohamed M.,Lin Danting,et al.The association of cerebrospinal fluid pressure with optic nerve head and macular vessel density[J].SCIENCE CHINA-LIFE SCIENCES.2022,65(6):1171-1180.doi:10.1007/s11427-021-1984-5.
APA：
Liu, Xiangxiang,Khodeiry, Mohamed M.,Lin, Danting,Sun, Yunxiao,Zhang, Qing...&Wang, Ningli.(2022).The association of cerebrospinal fluid pressure with optic nerve head and macular vessel density.SCIENCE CHINA-LIFE SCIENCES,65,(6)
MLA：
Liu, Xiangxiang,et al."The association of cerebrospinal fluid pressure with optic nerve head and macular vessel density".SCIENCE CHINA-LIFE SCIENCES 65..6(2022):1171-1180
生物学