机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA[3]Research Institute of Ophthalamology, Giza, Egypt[4]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China[5]Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China[6]Beijing Eye Institute, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[7]Department of Neurology and Medical Research Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China临床科室神经内科首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Purpose To investigate the changes in choroidal thickness (CT) after acute cerebrospinal fluid pressure (CSFP) reduction in human subjects. Methods Before and 15 minutes after diagnostic lumbar puncture (LP), 44 patients underwent measurement of CT by swept-source optical coherence tomography. Thirty-two healthy volunteers imitated the body posture of LP procedure and underwent the same measurement before and 15 minutes after body posture change. Results After CSFP reduction from 10.9 +/- 2.1 mmHg at baseline to 8.1 +/- 1.5 mmHg (p < 0.001), CT decreased in subfoveal region (p = 0.005), small to medium vessel layer (SMVL, p < 0.001), peripapillary regions in temporal (p = 0.001), nasal (p < 0.001), superior (p < 0.001) and inferior (p < 0.001), respectively. However, no significant change in CT in the control group after body posture change (all p > 0.05). A significant association between CSFP and the ratio of small to medium vessel layer to total choroidal thickness was found (p = 0.009). The CSFP reduction rate was associated with the change rate of SMVL to total CT portion, for each percent decrease in CSFP was associated with a decrease by 0.22% in the rate of SMVL to total CT portion (R-2 = 0.125, p = 0.018). Conclusions A significant decrease in subfoveal CT, small to medium vessel layer and peripapillary region were observed following acute CSFP reduction. The CSFP reduction rate was associated with the change rate of small to medium vessel layer to total CT portion.
第一作者机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China[2]Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA
通讯作者：
通讯机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China[6]Beijing Eye Institute, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China[*1]Beijing Eye Institute, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 1 Dongjiaominxiang Street, Dongcheng District, Beijing 100730, China.
推荐引用方式(GB/T 7714)：
Liu Xiangxiang,Khodeiry Mohamed M.,Lin Danting,et al.The Association of Acute Cerebrospinal Fluid Pressure Reduction with Choroidal Thickness[J].CURRENT EYE RESEARCH.2021,46(8):1193-1200.doi:10.1080/02713683.2021.1874024.
APA：
Liu, Xiangxiang,Khodeiry, Mohamed M.,Lin, Danting,Sun, Yunxiao,Lin, Caixia...&Wang, Ningli.(2021).The Association of Acute Cerebrospinal Fluid Pressure Reduction with Choroidal Thickness.CURRENT EYE RESEARCH,46,(8)
MLA：
Liu, Xiangxiang,et al."The Association of Acute Cerebrospinal Fluid Pressure Reduction with Choroidal Thickness".CURRENT EYE RESEARCH 46..8(2021):1193-1200
