MicroRNAs (miRNAs) have been documented to function differently in numerous human cancers. Our study planned to investigate the role of microRNA-140 (miR-140) and to identify its possible target in osteosarcoma (OS) to predict their mechanism in OS. The miR-140 was down-regulated in OS, and its high expression decreased MG63 cell proliferation. At the molecular level, Wnt1 was a target of miR-140, and its expression could be suppressed by miR-140. Besides, miR-140 overexpression decreased drug resistance in OS cells treated by doxorubicin. Collectively, overexpression of miR-140 may inhibit human OS cell proliferation and may enhance drug sensitivity by direct regulation of Wnt/??-catenin signaling.
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Foot & Ankle Surg Ctr, Beijing 100005, Peoples R China
推荐引用方式(GB/T 7714)：
Wang Zhi,Qu Feng,Zhang Mingzhu.MiR-140 targets Wnt1 to inhibit the proliferation and enhance drug sensitivity in osteosarcoma cells[J].CELLULAR AND MOLECULAR BIOLOGY.2022,68(1):140-146.doi:10.14715/cmb/2022.68.1.18.
APA：
Wang Zhi,Qu Feng&Zhang Mingzhu.(2022).MiR-140 targets Wnt1 to inhibit the proliferation and enhance drug sensitivity in osteosarcoma cells.CELLULAR AND MOLECULAR BIOLOGY,68,(1)
MLA：
Wang Zhi,et al."MiR-140 targets Wnt1 to inhibit the proliferation and enhance drug sensitivity in osteosarcoma cells".CELLULAR AND MOLECULAR BIOLOGY 68..1(2022):140-146
