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MicroRNA-26a induces osteosarcoma cell growth and metastasis via the Wnt/β-catenin pathway

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机构: [1]Capital Med Univ, Beijing Tongren Hosp, Dept Orthoped, Beijing 100730, Peoples R China [2]Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, 28 Faxing Rd, Beijing 100853, Peoples R China
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关键词: osteosarcoma microRNA-26a cell proliferation glycogen synthase kinase-3 beta microRNAs

摘要:
MicroRNAs (miRNAs/miRs) are a type of highly conserved, small non-coding RNA that are vital to the post-transcriptional regulation of gene expression via base pairing with target mRNA 3'-untranslated regions (3'-UTRs). Several studies have indicated that the abnormal expression of miRNAs occurs frequently in human osteosarcoma (OS). In the present study, the role of miR-26a in the progression and metastasis of OS was investigated using reverse transcription-quantitative polymerase chain reaction, a luciferase activity assay, cell viability assay, in vitro migration and invasion assays, transfection and western blot analysis. miR-26a was upregulated in OS tissues and cell lines, and the expression of miR-26a was indicated to affect the proliferation, migration and invasion of OS Saos-2 cells. At the molecular level, the results showed that glycogen synthase kinase-3 beta (GSK-3 beta) was identified as a target of miR-26a, and the ectopic expression of miR-26a inhibited GSK-3 beta by directly binding to the 3'-UTR. Therefore, the expression of miR-26a was negatively correlated with GSK-3 beta in the OS tissues. These data suggest that miR-26a is significant in the proliferation of human OS cells due to the direct regulation of Wnt/beta-catenin signaling.

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出版当年[2015]版:
大类 | 4 区 医学
小类 | 4 区 肿瘤学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 肿瘤学
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出版当年[2014]版:
Q4 ONCOLOGY
最新[2023]版:
Q3 ONCOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

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第一作者机构: [1]Capital Med Univ, Beijing Tongren Hosp, Dept Orthoped, Beijing 100730, Peoples R China [2]Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, 28 Faxing Rd, Beijing 100853, Peoples R China
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通讯机构: [2]Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, 28 Faxing Rd, Beijing 100853, Peoples R China [*1]Department of Orthopedics, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, Haidian, Beijing 100853, P.R. China
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