机构：[1]Upper Airway Research Laboratory, Ghent University, Ghent, Belgium[2]Department of Allergy, Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China临床科室耳鼻咽喉-头颈外科变态反应科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China研究所耳鼻咽喉科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[4]Division of ENT Diseases, CLINTEC, Karolinska Institute, Stockholm, Sweden[5]The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Department of Otorhinolaryngology, International Airway Research Center, Guangzhou, China中山大学附属第一医院
In the last 2 decades, an increasing understanding of pathophysiological mechanisms in chronic rhinosinusitis (CRS) opened an avenue from phenotyping to endotyping, from eosinophilic inflammation to type 2 immunity, and from the ventilation and drainage paradigm to the mucosal concept for therapeutic considerations. With the advent of type 2 endotyping and targeted biomarkers, precise endotype-driven therapeutic options are possible including biologics and adapted surgical approaches. We here aim to focus on the complexity and heterogeneity of the features of CRS endotypes, especially for those with nasal polyps, including its history, latest developments, clinical associations, and endotype-driven solutions. In order to better manage uncontrolled severe CRS in clinical practice, medical decisions based on a profound understanding of the pathology and immunology of this heterogeneous disease, aiding a precision-medicine based approach for patient's treatment, are pivotal. (C) 2021 American Academy of Allergy, Asthma & Immunology
第一作者机构：[1]Upper Airway Research Laboratory, Ghent University, Ghent, Belgium[2]Department of Allergy, Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[2]Department of Allergy, Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China[3]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China[4]Division of ENT Diseases, CLINTEC, Karolinska Institute, Stockholm, Sweden[5]The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Department of Otorhinolaryngology, International Airway Research Center, Guangzhou, China[*1]Beijing Institute of Otolaryngology, 17, HouGouHuTong, DongCheng District, Beijing, 100005, China[*2]Upper Airways Research Laboratory (URL), University Hospital Ghent, Corneel Heymanslaan 10, B-9000, Ghent, Belgium.
推荐引用方式(GB/T 7714)：
Huang Yanran,Zhang Nan,Xu Zhaofeng,et al.The Development of the Mucosal Concept in Chronic Rhinosinusitis and Its Clinical Implications[J].JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE.2022,10(3):707-715.doi:10.1016/j.jaip.2021.10.054.
APA：
Huang, Yanran,Zhang, Nan,Xu, Zhaofeng,Zhang, Luo&Bachert, Claus.(2022).The Development of the Mucosal Concept in Chronic Rhinosinusitis and Its Clinical Implications.JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE,10,(3)
MLA：
Huang, Yanran,et al."The Development of the Mucosal Concept in Chronic Rhinosinusitis and Its Clinical Implications".JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE 10..3(2022):707-715
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