机构：[1]Shanghai Jiao Tong Univ, Tongren Hosp, Dept Cardiol, Sch Med, Shanghai, Peoples R China[2]Tongji Univ, Dept Gen Surg, Shanghai Peoples Hosp 4, Sch Med, Shanghai, Peoples R China[3]Natl Ctr Human Genet Resources, Natl Res Inst Family Planning, Beijing, Peoples R China[4]Beijing Hypertens League Inst, Beijing, Peoples R China
Background The variant of ALDH2 was thought to be associated with Acute Myocardial Infarction (AMI) due to the consumption of alcohol. This study focused on how ALDH2 variant acts as an independent risk factor for AMI, regardless of alcohol consumption. Methods and results We used the case-control INTERHEART-China study which took place at 25 centres in 17 cities in mainland China. Cases were patients with AMI and matched by age, sex, and site to controls. Information about alcohol consumption and genotype were collected. We divided cases and controls by alcohol consumption: alcohol intake group and no alcohol intake group. Then, calculated the Odd Ratio (OR) value with confidence interval (CI) at 95% level to find the association between ALDH2 variant and AMI. Results were then adjusted by sex, age, BMI, and other common risk factors of AMI. The study involves a total of 2660 controls and 2322 AMI patients. The no drink intake group showed that there was a correlation between the ALDH2 variant and AMI (OR = 1.236, 95% CI = 1.090-1.401, p = 0.00092). After adjustment of different risk factors this association remained (OR = 1.247, 95% CI = 1.099-1.415, p = 0.00062). Similar results were also obtained from the no alcohol intake group (OR = 1.196, 95% CI = 0.993-1.440, p = 0.05963), however, due to the limited sample size, the result was not significant enough statistically. Conclusion From our results, ALDH2 variant is associated with the risk of AMI even in population that has no alcohol consumption. This suggests that ALDH2 variant may act as an independent risk factor for AMI.
基金：
Shanghai Natural Science Foundation [22ZR1480800]; Beijing Hypertension League Institute; National Center for Human Genetic Resources, National Research Institute for Family Planning; Shanghai Jiao Tong University School of Medicine; National Human Genetic Resources Sharing Service Platform
第一作者机构：[1]Shanghai Jiao Tong Univ, Tongren Hosp, Dept Cardiol, Sch Med, Shanghai, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[3]Natl Ctr Human Genet Resources, Natl Res Inst Family Planning, Beijing, Peoples R China[4]Beijing Hypertens League Inst, Beijing, Peoples R China
推荐引用方式(GB/T 7714)：
Jiang Qixia,Li Xiaoguang,Chen Rukun,et al.Association of functional variant of aldehyde dehydrogenase 2 with acute myocardial infarction of Chinese patients[J].BMC CARDIOVASCULAR DISORDERS.2022,22(1):doi:10.1186/s12872-022-02738-y.
APA：
Jiang, Qixia,Li, Xiaoguang,Chen, Rukun,Wang, Chuhong,Liu, Xin&Wang, Xingyu.(2022).Association of functional variant of aldehyde dehydrogenase 2 with acute myocardial infarction of Chinese patients.BMC CARDIOVASCULAR DISORDERS,22,(1)
MLA：
Jiang, Qixia,et al."Association of functional variant of aldehyde dehydrogenase 2 with acute myocardial infarction of Chinese patients".BMC CARDIOVASCULAR DISORDERS 22..1(2022)
