Bio-implants are widely used in clinic for repair defected bone, however, clinical trace always found that the poor osseointegration often results in bone repair failure. In this study, we investigated whether simvastatin loaded onto sulfonated PEEK (SP) surfaces enhances the bone formation effect of the SP samples. Our results showed that simvastatin loading could significantly enhance the formation of type H vessels, which are pivotal and specific vessels showing strong association with bone formation. Further, osteogenesis was found to be strongly correlated with simvastatin release. Based on experiments involving miR-29cb2 knockout and bone defect mice, simvastatin upregulated the expression of miR-29cb2, which suppressed HIF-3 alpha expression, leading to the promotion of osseointegration and angiogenesis.
基金：
National Natural Science Foundation of China (32071344, 32000938, U21A20100, 81403029), Natural Science Foundation of Shanghai, China (19ZR1449100), High-end Entrepreneurial and Innovative Teams of Ningbo High-level Talents Project (2018A-09-C), Shenzhen Science and Technology Funding (JCYJ20210324120009026), and S&T Innovation 2025 Major Special Program of Ningbo (2018B10040) are acknowledged.
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2021]版：
大类|1 区工程技术
小类|1 区工程：环境1 区工程：化工
最新[2025]版：
大类|1 区材料科学
小类|1 区工程：化工1 区工程：环境
JCR分区：
出版当年[2020]版：
Q1ENGINEERING, ENVIRONMENTALQ1ENGINEERING, CHEMICAL
第一作者机构：[1]Shanghai Jiao Tong Univ, Tongren Hosp, Dept Pharm, Sch Med, Shanghai 200336, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Shanghai Jiao Tong Univ, Tongren Hosp, Dept Pharm, Sch Med, Shanghai 200336, Peoples R China[2]Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine M, Shanghai 200050, Peoples R China[3]Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China[4]Shanghai Jiao Tong Univ, Hongqiao Int Inst Med, Sch Med, Shanghai 200336, Peoples R China[5]Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Chem & Mat Sci, 1 Sub lane Xiangshan, Hangzhou 310024, Peoples R China[6]Cixi Ctr Biomat Surface Engn, Ningbo 315300, Peoples R China[*1]Department of Pharmacy, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China[*2]Department of Pharmacy, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China
推荐引用方式(GB/T 7714)：
Sun Yingxiao,Liu Xingdan,Zeng Xiaoling,et al.Simvastatin-loaded sulfonated PEEK enhances angiogenesis and osteogenesis via miR-29cb2-mediated HIF-3 alpha downregulation[J].CHEMICAL ENGINEERING JOURNAL.2022,448:doi:10.1016/j.cej.2022.137738.
APA：
Sun, Yingxiao,Liu, Xingdan,Zeng, Xiaoling,Wang, Luping,Jin, Zhao...&Liao, Yun.(2022).Simvastatin-loaded sulfonated PEEK enhances angiogenesis and osteogenesis via miR-29cb2-mediated HIF-3 alpha downregulation.CHEMICAL ENGINEERING JOURNAL,448,
MLA：
Sun, Yingxiao,et al."Simvastatin-loaded sulfonated PEEK enhances angiogenesis and osteogenesis via miR-29cb2-mediated HIF-3 alpha downregulation".CHEMICAL ENGINEERING JOURNAL 448.(2022)
工程技术