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The significance of the detection of serum lactate dehydrogenase, hypersensitive C-reactive protein, and N-terminal pro-brain natriuretic peptide for the evaluation of the severity and progression of pediatric patients with traumatic brain injury

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收录情况： ◇ SCIE

作者：
Liu Yu[1] * ; Yang Peng[2] * ; Liu Hao-Cheng[2] ; Sun Si[2] ; Zhang Jia-Liang[2] ; Kang Jun[2,*1] ;
机构： [1]Department of Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China [2]Department of Neurosurgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
出处：
DOI： 10.2174/1567202619666220713110941
ISSN：

关键词： Traumatic brain injury serum lactate dehydrogenase (LDH) N-terminal pro-brain natriuretic peptide (NTproBNP) hypersensitive C-reactive protein (hs-CRP) prognosis

摘要：
This study aimed to investigate changes in the levels of serum lactate dehydrogenase (LDH), hypersensitive C-reactive protein (hs-CRP), and N-terminal pro-brain natriuretic peptide (NT-proBNP) in pediatric patients with traumatic brain injury and the clinical significance of detecting these changes for the evaluation of injury severity and patient progress.A retrospective study was conducted of 40 pediatric patients admitted to the Tongren Hospital of China Capital Medical University with traumatic brain injury between January 2018 and December 2019. Immunoturbidimetric assay and electrochemiluminescence were used to detect the serum levels of LDH, hs-CRP, and NT-proBNP. Correlation analysis was used to determine the degree of association between the indicators and the sensitivity and specificity of each indicator.The serum levels of LDH, hs-CRP, and NT-proBNP in the poor-prognosis group were higher than those in the good-prognosis group, and the differences were statistically significant (P < 0.05).The detection of serum LDH, hs-CRP, and NT-proBNP might be of great significance for the evaluation of the severity of a traumatic brain injury, disease progression, and the prognosis of pediatric patients with traumatic brain injury. The combined detection of the relevant indicators could provide more effective sensitivity and specificity and therefore offer better guidance and assistance in clinical practice.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

语种：
外文
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WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 4 区 医学
小类 | 4 区 临床神经病学 4 区 神经科学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 临床神经病学 4 区 神经科学
JCR分区：
出版当年[2020]版：
Q4 NEUROSCIENCES Q4 CLINICAL NEUROLOGY
最新[2023]版：
Q3 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Department of Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
共同第一作者：
通讯作者：
通讯机构： [2]Department of Neurosurgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China [*1]Department of Neurosurgery, Tongren Hospital of China Capital Medical University, Beijing 100730, China
推荐引用方式(GB/T 7714)：
Liu Yu,Yang Peng,Liu Hao-Cheng,et al.The significance of the detection of serum lactate dehydrogenase, hypersensitive C-reactive protein, and N-terminal pro-brain natriuretic peptide for the evaluation of the severity and progression of pediatric patients with traumatic brain injury[J].CURRENT NEUROVASCULAR RESEARCH.2022,19(2):219-224.doi:10.2174/1567202619666220713110941.
APA：
Liu Yu,Yang Peng,Liu Hao-Cheng,Sun Si,Zhang Jia-Liang&Kang Jun.(2022).The significance of the detection of serum lactate dehydrogenase, hypersensitive C-reactive protein, and N-terminal pro-brain natriuretic peptide for the evaluation of the severity and progression of pediatric patients with traumatic brain injury.CURRENT NEUROVASCULAR RESEARCH,19,(2)
MLA：
Liu Yu,et al."The significance of the detection of serum lactate dehydrogenase, hypersensitive C-reactive protein, and N-terminal pro-brain natriuretic peptide for the evaluation of the severity and progression of pediatric patients with traumatic brain injury".CURRENT NEUROVASCULAR RESEARCH 19..2(2022):219-224

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