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Rhein inhibits endometriosis by targeting microRNA-135

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机构： [1]Wuhan Univ, Wuhan Hosp 3, Dept Obstet & Gynecol, Tongren Hosp, Wuhan 430060, Peoples R China [2]Hubei Prov Hosp Integrated Chinese & Western Med, Dept Obstet & Gynecol, Wuhan 430015, Peoples R China

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关键词： endometriosis rhein rhubarb proliferation micro-RNA miR-135 invasion

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Endometriosis is a serious human gynecological disorder of women of reproductive age. The present study was designed to explore the therapeutic implications of rhein in the management of endometriosis. The results showed that rhein significantly (p<0.05) inhibited the proliferation of endometrial stroma cells in a dose-dependent fashion. Besides, the rhein treated endometrial stroma cells showed significantly (p<0.05) lower migration and invasion, in vitro. Transwell and wound healing assays showed that rhein also suppressed the migration and invasion of the endometrial stroma cells. Rhein was shown to target miR-135 at the molecular level to exert its anti-proliferative effects against the human endometrial stroma cells. Conversely, overexpression of miR-135 could nullify the anti-proliferative effects of rhein. Taken together, the findings of the present study highlight the therapeutic utility of rhein against human endometriosis. However, more in vivo studies are required.

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出版当年[2021]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学

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出版当年[2020]版：

Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 1.4 最新[2023版] 1.8 最新五年平均 2.149 出版当年[2020版] 2.175 出版当年五年平均 1.42 出版前一年[2019版] 2.349 出版后一年[2021版]

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第一作者机构： [1]Wuhan Univ, Wuhan Hosp 3, Dept Obstet & Gynecol, Tongren Hosp, Wuhan 430060, Peoples R China

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