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Optic nerve lesion length is a biomarker of visual disability in the pre-chronic phase of Leber?s hereditary optic neuropathy

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机构： [1]Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, China. [2]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, China

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关键词： Optic nerve Lesion length Subacute Dynamic LHON

摘要：

The current research aims to investigate relationships between the optic nerve (ON) lesion length with visual function in the pre-chronic phase ( illness duration < 12 months) of LHON.Orbital MRI was retrospectively analyzed for 45 patients with LHON in the pre-chronic phase. ON lesion length was measured by 2 trained independent readers and it was recorded as multiplication of the number of abnormal MRI slices and slice thickness on T2-STIR sequence in the coronal plane. Decimal visual acuity was converted to the logarithm of minimum angle of resolution. Intra-class correlation coefficients (ICCs) were used to assess intra- and inter-observer agreements. Pearson's correlation analysis and multivariate linear regression models were performed to analyze the correlations of the lesion length with best corrected visual acuity (BCVA) and visual field parameters.81 afflicted eyes were selected. The ICCs for intra-observer and inter-observer analyses were 0.989 and 0.980 respectively. Both Pearson's correlation analysis and multivariate linear regression models indicated a significant positive correlation between the BCVA or mean deviation (MD) and ON lesion length (rBCVA=0.368, PBCVA=0.001; rMD=-0.269, PMD=0.045) with a coefficient of determination (R2) of 0.152 and 0.114 respectively adjusted for patients' sex, age of onset, onset of vision loss to performance of MRI, mitochondrial DNA mutations.ON length with T2-STIR hyperintensities was positively associated with both BCVA and MD, and it was suspected to be a biomarker of visual disability in the pre-chronic phase of LHON.Copyright © 2022 Elsevier B.V. All rights reserved.

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出版当年[2022]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区外科

最新[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区外科

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出版当年[2021]版：

Q3 SURGERY Q4 CLINICAL NEUROLOGY

最新[2023]版：

Q2 SURGERY Q3 CLINICAL NEUROLOGY

影响因子： 1.8 最新[2023版] 1.8 最新五年平均 1.885 出版当年[2021版] 2.11 出版当年五年平均 1.876 出版前一年[2020版] 1.9 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, China.

通讯作者：

通讯机构： [1]Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, China. [*1]Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Yizhuang Economic and Technological Development Zone, No. 2, Xihuan South Road, Beijing 100176, China

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