Thyroid cancer (THCA) is one of the commonest malignancies associated with increased recurrence. Therefore, identifying the putative molecular markers and therapeutic targets to improve the treatment of THCA is essential. The present study analyzed the potential role of tripartite motif-containing 21 (TRIM21), a member of the TRIM family belonging to the subfamily of E3 ubiquitin ligases, in the progression of THCA. Using bioinformatics analysis and immunohistochemistry of THCA tissues, it was observed that TRIM21 is overexpressed in THCA tissues. The present study also found that TRIM21 is associated with lymph node metastasis and high-risk recurrence of THCA. Furthermore, it identified a promotional role of TRIM21 in THCA cell migration and invasion. In addition, the present study analyzed TRIM21-enriched pathways and co-expressed genes in THCA. The present study suggested that TRIM21 may serve as a potential biomarker for THCA prognosis.
基金：
Science and Technology Project of Shandong Society of Geriatrics; Medical and Health Science project of Shandong Province [LKJGG2021W069]; [202104010413]
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100730, Peoples R China[2]Capital Med Univ, Beijing Tongren Hosp, Dept Thyroid Surg, Beijing 100730, Peoples R China[3]Liaocheng Peoples Hosp, Dept Thyroid & Breast Surg, Liaocheng 252000, Shandong, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100730, Peoples R China[2]Capital Med Univ, Beijing Tongren Hosp, Dept Thyroid Surg, Beijing 100730, Peoples R China[3]Liaocheng Peoples Hosp, Dept Thyroid & Breast Surg, Liaocheng 252000, Shandong, Peoples R China[*1]Department of Otorhinolaryngology Head and Neck Surgery and Department of Thyroid Surgery, Beijing Tongren Hospital, Capital Medical University, 1 Dongjiaomin Street, Beijing 100730, P.R. China[*2]Department of Thyroid and Breast Surgery, Liaocheng People's Hospital, 67 Dongchangxi Road, Liaocheng, Shandong 252000, P.R. China
推荐引用方式(GB/T 7714)：
Wu Zhen,Wang Yongkun,Yu Zhengya,et al.TRIM21-a potential biomarker for the prognosis of thyroid cancer[J].EXPERIMENTAL AND THERAPEUTIC MEDICINE.2022,24(6):doi:10.3892/etm.2022.11697.
APA：
Wu, Zhen,Wang, Yongkun,Yu, Zhengya,Meng, Zhen,Duan, Wenchao...&Fang, Jugao.(2022).TRIM21-a potential biomarker for the prognosis of thyroid cancer.EXPERIMENTAL AND THERAPEUTIC MEDICINE,24,(6)
MLA：
Wu, Zhen,et al."TRIM21-a potential biomarker for the prognosis of thyroid cancer".EXPERIMENTAL AND THERAPEUTIC MEDICINE 24..6(2022)
