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Mechanosensitive channel Piezo1 is an essential regulator in cell cycle progression of optic nerve head astrocytes

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收录情况： ◇ SCIE

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机构： [1]Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Inst Ophthalmol,Beijing Ophthalmol & Visua, Beijing 100730, Peoples R China [2]Tsinghua Univ, IDG McGovern Inst Brain Res, Tsinghua Peking Ctr Life Sci, Beijing Frontier Res Ctr Biol Struct,Sch Pharmaceu, Beijing, Peoples R China

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关键词： cell proliferation optic nerve head astrocyte Piezo1 YAP

摘要：

Optic nerve head (ONH) astrocytes provide structural and metabolic support to neuronal axons in developmental, physiological, and pathological progression. Mechanosensitive properties of astrocytes allow them to sense and respond to mechanical cues from the local environment. We confirmed that ONH astrocytes express the mechanosensitive ion channel Piezo1 in vivo. By manipulating Piezo1 knockdown or overexpression in vitro, we found that Piezo1 is necessary but insufficient for ONH astrocyte proliferation. Loss of Piezo1 can lead to cell cycle arrest at G0/G1 phase, a possible mechanism involving decreased yes-associated protein (YAP) nuclear localization and downregulation of YAP-target cell cycle-associated factors, including cyclin D1 and c-Myc. Gene ontology enrichment analysis of differential expression genes from RNA-seq data indicates that the absence of Piezo1 affects biological processes involving cell division. Our results demonstrate that Piezo1 is an essential regulator in cell cycle progression in ONH astrocytes.

基金：

基金编号： 81730027 82130029

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出版当年[2022]版：

大类 | 1 区

医学

小类 | 2 区神经科学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区神经科学

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出版当年[2021]版：

Q1 NEUROSCIENCES

最新[2023]版：

Q1 NEUROSCIENCES

影响因子： 5.4 最新[2023版] 6.6 最新五年平均 8.073 出版当年[2021版] 7.956 出版当年五年平均 7.452 出版前一年[2020版] 6.2 出版后一年[2022版]

第一作者：

第一作者机构： [1]Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Inst Ophthalmol,Beijing Ophthalmol & Visua, Beijing 100730, Peoples R China

通讯作者：

通讯机构： [1]Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Inst Ophthalmol,Beijing Ophthalmol & Visua, Beijing 100730, Peoples R China [*1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & Visual Sciences Key Laboratory, Capital Medical University, Beijing 100730, China.

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