机构:[1]Department of Respiratory and Critical Care Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China.首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Laboratory Medicine, Shunyi District Hospital of Beijing, Beijing, China.[3]Department of Laboratory Medicine, Guangzhou Women and Children's Medical Center, Guangzhou, China.[4]Department of Laboratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China.医技科室检验科首都医科大学附属北京同仁医院首都医科大学附属同仁医院
To determine the effect of fasting plasma glucose (FPG) level at admission affects the 90-day mortality rate in patients with viral pneumonia.Two hundred fifty viral pneumonia patients were stratified into normal FPG (FPG<7.0 mmol/L), moderately-elevated FPG (FPG=7.0-14.0 mmol/L), and highly-elevated FPG groups (FPG≥14.0 mmol/L) according to the FPG level at the time of admission. The clinical characteristics, etiologies, and prognosis of different groups of patients were compared. Kaplan-Meier survival and Cox regression analyses were used to determine the relationship between the FPG level and 90-day all-cause mortality rate in patients with viral pneumonia.Patients in the moderately- and highly-elevated FPG groups had a higher proportion of severe disease and mortality compared with the normal FPG group (P<0.001). Kaplan-Meier survival analysis showed a significant trend toward higher mortality and increased cumulative risk at 30, 60, and 90 d in patients with an FPG=7.0-14.0 mmol/L and an FPG≥14 mmol/L (χ2=51. 77, P<0.001). Multivariate Cox regression analysis revealed that compared with an FPG<7.0 mmol/L, FPG=7.0 and 14.0 mmol/L (HR: 9.236, 95% CI: 1.106-77.119, P=0.040) and FPG≥14.0 mmol/L (HR: 25.935, 95% CI: 2.586-246.213, P=0.005) were independent risk factors for predicting the 90-day mortality rate in viral pneumonia patients.The higher the FPG level at admission in a patient with viral pneumonia, the higher the risk of all-cause mortality within 90 d.Thieme. All rights reserved.
基金:
research on the pathogenic diagnosis
of acute and severe respiratory infectious diseases in general
hospitals (2014ZX10004005) and research on relevant technical
specifications and standard systems of biosafety sample banks
(SQ2019YFC120021).
第一作者机构:[1]Department of Respiratory and Critical Care Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
通讯作者:
通讯机构:[4]Department of Laboratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China.[*1]Department of Laboratory Medicine, Beijing Tongren Hospital, Capital Medical University, No. 1, Dongjiaomin Lane, Dongcheng District 100730 Beijing China
推荐引用方式(GB/T 7714):
Xu Jie,Zhao Jianyu,Wu Liyuan,et al.Fasting Plasma Glucose Levels at the Time of Admission Predict 90-Day Mortality in Patients with Viral Pneumonia. A Prospective Study[J].EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES.2023,131(05):290-298.doi:10.1055/a-2045-7787.
APA:
Xu Jie,Zhao Jianyu,Wu Liyuan&Lu Xinxin.(2023).Fasting Plasma Glucose Levels at the Time of Admission Predict 90-Day Mortality in Patients with Viral Pneumonia. A Prospective Study.EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES,131,(05)
MLA:
Xu Jie,et al."Fasting Plasma Glucose Levels at the Time of Admission Predict 90-Day Mortality in Patients with Viral Pneumonia. A Prospective Study".EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES 131..05(2023):290-298