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Fasting Plasma Glucose Levels at the Time of Admission Predict 90-Day Mortality in Patients with Viral Pneumonia. A Prospective Study

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机构: [1]Department of Respiratory and Critical Care Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [2]Department of Laboratory Medicine, Shunyi District Hospital of Beijing, Beijing, China. [3]Department of Laboratory Medicine, Guangzhou Women and Children's Medical Center, Guangzhou, China. [4]Department of Laboratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
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关键词: viral pneumonia fasting plasma glucose level type 2 diabetes survival analysis

摘要:
To determine the effect of fasting plasma glucose (FPG) level at admission affects the 90-day mortality rate in patients with viral pneumonia.Two hundred fifty viral pneumonia patients were stratified into normal FPG (FPG<7.0 mmol/L), moderately-elevated FPG (FPG=7.0-14.0 mmol/L), and highly-elevated FPG groups (FPG≥14.0 mmol/L) according to the FPG level at the time of admission. The clinical characteristics, etiologies, and prognosis of different groups of patients were compared. Kaplan-Meier survival and Cox regression analyses were used to determine the relationship between the FPG level and 90-day all-cause mortality rate in patients with viral pneumonia.Patients in the moderately- and highly-elevated FPG groups had a higher proportion of severe disease and mortality compared with the normal FPG group (P<0.001). Kaplan-Meier survival analysis showed a significant trend toward higher mortality and increased cumulative risk at 30, 60, and 90 d in patients with an FPG=7.0-14.0 mmol/L and an FPG≥14 mmol/L (χ2=51. 77, P<0.001). Multivariate Cox regression analysis revealed that compared with an FPG<7.0 mmol/L, FPG=7.0 and 14.0 mmol/L (HR: 9.236, 95% CI: 1.106-77.119, P=0.040) and FPG≥14.0 mmol/L (HR: 25.935, 95% CI: 2.586-246.213, P=0.005) were independent risk factors for predicting the 90-day mortality rate in viral pneumonia patients.The higher the FPG level at admission in a patient with viral pneumonia, the higher the risk of all-cause mortality within 90 d.Thieme. All rights reserved.

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出版当年[2022]版:
大类 | 4 区 医学
小类 | 4 区 内分泌学与代谢
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 内分泌学与代谢
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出版当年[2021]版:
Q4 ENDOCRINOLOGY & METABOLISM
最新[2023]版:
Q4 ENDOCRINOLOGY & METABOLISM

影响因子: 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

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第一作者机构: [1]Department of Respiratory and Critical Care Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
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通讯机构: [4]Department of Laboratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [*1]Department of Laboratory Medicine, Beijing Tongren Hospital, Capital Medical University, No. 1, Dongjiaomin Lane, Dongcheng District 100730 Beijing China
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