机构：[1]Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China首都医科大学附属天坛医院[2]Department of Neurosurgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China临床科室神经外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Department of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China首都医科大学附属天坛医院[4]Department of Neurosurgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China[5]Chinese Glioma Genome Atlas Network and Asian Glioma Genome Atlas Network, Beijing 100070, China[6]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China首都医科大学附属天坛医院[7]Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing 100069, China[8]China National Clinical Research Center for Neurological Diseases, Beijing 100070, China[9]Research Unit of Accurate Diagnosis, Treatment, and Translational Medicine of Brain Tumors, Chinese Academy of Medical Sciences, Beijing 100070, China
Polymerase I and transcript release factor (PTRF) plays a role in the regulation of gene expression and the release of RNA transcripts during transcription, which have been associated with various human diseases. However, the role of PTRF in glioma remains unclear. In this study, RNA sequencing (RNA-seq) data (n = 1022 cases) and whole-exome sequencing (WES) data (n = 286 cases) were used to characterize the PTRF expression features. Gene ontology (GO) functional enrichment analysis was used to assess the biological implication of changes in PTRF expression. As a result, the expression of PTRF was associated with malignant progression in gliomas. Meanwhile, somatic mutational profiles and copy number variations (CNV) revealed the glioma subtypes classified by PTRF expression showed distinct genomic alteration. Furthermore, GO functional enrichment analysis suggested that PTRF expression was associated with cell migration and angiogenesis, particularly during an immune response. Survival analysis confirmed that a high expression of PTRF is associated with a poor prognosis. In summary, PTRF may be a valuable factor for the diagnosis and treatment target of glioma.
基金：
This work was supported by the Brain Tumor Precision Diagnosis and
Treatment and Translational Medicine Innovation Unit of Chinese Academy
of Medical Sciences (2019-I2M-5–021), Beijing Hospitals Authority Youth
Programme (QML20230507), and Beijing Municipal Health Commission Fund
(11000023T000002044300-5).
第一作者机构：[1]Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China[2]Department of Neurosurgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
共同第一作者：
通讯作者：
通讯机构：[1]Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China[5]Chinese Glioma Genome Atlas Network and Asian Glioma Genome Atlas Network, Beijing 100070, China[6]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China[7]Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing 100069, China[8]China National Clinical Research Center for Neurological Diseases, Beijing 100070, China[9]Research Unit of Accurate Diagnosis, Treatment, and Translational Medicine of Brain Tumors, Chinese Academy of Medical Sciences, Beijing 100070, China
推荐引用方式(GB/T 7714)：
Sun Si,Yang Changlin,Wang Kuanyu,et al.Molecular and clinical characterization of PTRF in glioma via 1,022 samples[J].BMC CANCER.2023,23(1):doi:10.1186/s12885-023-11001-2.
APA：
Sun, Si,Yang, Changlin,Wang, Kuanyu,Huang, Ruoyu,Zhang, Ke-nan...&Jiang, Tao.(2023).Molecular and clinical characterization of PTRF in glioma via 1,022 samples.BMC CANCER,23,(1)
MLA：
Sun, Si,et al."Molecular and clinical characterization of PTRF in glioma via 1,022 samples".BMC CANCER 23..1(2023)
医学