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Induction chemotherapy-based organ-preservation protocol improve the function preservation compared with immediate total laryngectomy for locally advanced hypopharyngeal cancer-Results of a matched-pair analysis

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Yang Yifan[1,2] * ; Feng Ling[1,2] ; Zhong Qi[1,2] ; Zhang Yang[1,2] ; Huang Zhigang[1,2] ; Zhang Shurong[3] ; Li Shuling[4] ; Gao Junmao[5] ; Hou Lizhen[1,2] ; Ma Hongzhi[1,2] ; He Shizhi[1,2] ; Shi Qian[1,2] ; Lian Meng[1,2] ; Zhao Yanming[1,2] ; Shen Xixi[1,2] ; Chen Jiaming[1,2] ; Wang Lingwa[1,2] ; Li Haiyang[1,2] ; Chen Shaoshi[1,2] ; Xu Jiaqi[1,2] ; Wang Ru[1,2] ; Fang Jugao[1,2] ;
机构： [1]Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University, Beijing, China. [2]Key Laboratory of Otorhinolaryngology, Head and Neck Surgery, Beijing Institute of Otorhinolaryngology, Beijing, China. [3]Department of Oncology, Beijing Tong Ren Hospital, Capital Medical University, Beijing, China. [4]Department of Radiology, Beijing Tong Ren Hospital, Capital Medical University, Beijing, China. [5]Department of Radiotherapy, Seventh Medical Center, General Hospital of the Chinese People's Liberation Army, Beijing, China.
出处：
DOI： 10.1002/cam4.6354
ISSN：

关键词： chemotherapy hypopharyngeal cancer laryngectomy organ preservation surgery

摘要：
We performed a paired analysis to compare the therapeutic effect between the induction chemotherapy-based organ-preservation approach and immediate total laryngectomy in hypopharyngeal squamous cell carcinoma patients requiring total laryngectomy.351 patients who were treated with organ-preservation approach were compared with 110 patients who were treated with total laryngectomy. The main measures and outcomes were progression-free survival (PFS), overall survival (OS), and larynx function preservation survival (LFPS).No statistical difference was observed for 3-, 5-, and 10-year PFS and OS in two groups. In the organ-preservation group, the 3-, 5-, and 10-year LFPS was 30.7%, 23.3%, and 16.6%, respectively. The LFPS of Stage III > Stage IV, N0 > N1 > N2 > N3, T2 > T3 > T4, CR > PR > SD > PD patients (all p values <0.05).Survival outcomes did not significantly differ between the two groups. The organ-preservation approach allowed more than 70% of the survivors to retain their larynx function.© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

基金：
Beijing Hospitals Authority Youth Programme, Grant/Award Number: QML20230206; Beijing Municipal Administration of Hospitals’ Ascent Plan, Grant/Award Number: DFL20180202; Beijing Natural Science Foundation Program, Scientific Research Key Program of Beijing Municipal Commission of Education, Grant/Award Number: KZ201910025034; Capital Health Research and Development of Special Fund, Grant/Award Number: 2018-2- 2054; National Key R&D Program of China, Grant/Award Number: 2020YFB1312805
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 3 区 肿瘤学
最新[2023]版：
大类 | 2 区 医学
小类 | 3 区 肿瘤学
JCR分区：
出版当年[2021]版：
Q2 ONCOLOGY
最新[2023]版：
Q2 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University, Beijing, China. [2]Key Laboratory of Otorhinolaryngology, Head and Neck Surgery, Beijing Institute of Otorhinolaryngology, Beijing, China.
通讯作者：
通讯机构： [1]Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University, Beijing, China. [2]Key Laboratory of Otorhinolaryngology, Head and Neck Surgery, Beijing Institute of Otorhinolaryngology, Beijing, China.
推荐引用方式(GB/T 7714)：
Yang Yifan,Feng Ling,Zhong Qi,et al.Induction chemotherapy-based organ-preservation protocol improve the function preservation compared with immediate total laryngectomy for locally advanced hypopharyngeal cancer-Results of a matched-pair analysis[J].CANCER MEDICINE.2023,12(16):17078-17086.doi:10.1002/cam4.6354.
APA：
Yang Yifan,Feng Ling,Zhong Qi,Zhang Yang,Huang Zhigang...&Fang Jugao.(2023).Induction chemotherapy-based organ-preservation protocol improve the function preservation compared with immediate total laryngectomy for locally advanced hypopharyngeal cancer-Results of a matched-pair analysis.CANCER MEDICINE,12,(16)
MLA：
Yang Yifan,et al."Induction chemotherapy-based organ-preservation protocol improve the function preservation compared with immediate total laryngectomy for locally advanced hypopharyngeal cancer-Results of a matched-pair analysis".CANCER MEDICINE 12..16(2023):17078-17086

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