机构：[1]Department of Ophthalmology, University of Ottawa, Ottawa, Canada.[2]Pediatric Oncology Center, Beijing Children's Hospital, Capital Medical University, Beijing, China.首都医科大学附属北京儿童医院[3]Department of Ophthalmology, Beijing Children's Hospital, Capital Medical University, Beijing, China.首都医科大学附属北京儿童医院[4]Department of Pathology, Beijing Children's Hospital, Capital Medical University, Beijing, China.首都医科大学附属北京儿童医院[5]Department of Medical Oncology, Beijing Children's Hospital, Capital Medical University, Beijing, China.首都医科大学附属北京儿童医院[6]Beijing Key Laboratory of Pediatric Hematology Oncology, Key Laboratory of Major Diseases in Children, Beijing, China.[7]Department of Ophthalmology, Hospital for Sick Children, Toronto, Canada.[8]Krembil Research Institute and Techna Institute, University Health Network, Toronto, Canada.[9]Departments Ophthalmology, Medical Biophysics and Molecular Genetics, University of Toronto, Toronto, Canada.
The purpose of this study was to investigate the effect of adjuvant chemotherapy on outcomes of children with massive choroidal invasion (MCI).In this study, we reviewed the 5-year relapse-free survival (RFS) and overall survival (OS) of children diagnosed with MCI, managed with or without adjuvant chemotherapy. Excluded were children with additional other high-risk features (post-laminar optic nerve invasion, scleral invasion, or overt extraocular disease).Of 3566 children diagnosed with retinoblastoma, 2023 had enucleation, and 60 eyes of 60 children had pathology showing MCI without concomitant high-risk features. Enucleation was primary (22, 37%), or secondary (38, 63%) after failed eye salvage. Adjuvant systemic chemotherapy (median = 4, range = 1-8 cycles) was given to 48 of 60 (80%) children; 12 of 60 (20%) children had no adjuvant therapy. Five-year RFS was 88.5% (95% confidence interval [CI] = 79.7%-97.3%) and 5-year OS was 90.1% (95% CI = 81.7%-98.5%). Pre-enucleation chemotherapy did not affect RFS (89.7% vs. 75.0%; P = 0.657). Adjuvant chemotherapy improved RFS (97.2% vs. 55.6%; P < 0.001) and OS (97.2% vs. 66.7%; P < 0.001). In subgroup analysis, adjuvant chemotherapy improved RFS for both primarily enucleated (5-year RFS 100% vs. 50.0%; P = 0.002) and secondarily enucleated children (5-year RFS 95.8% vs. 60.0%; P = 0.005). The number of children treated with adjuvant chemotherapy to prevent one post-enucleation systemic relapse or death is three.Adjuvant chemotherapy significantly decreased the risk of tumor relapse and death for children with pathological MCI. For every three children treated with adjuvant chemotherapy, one systemic relapse or death could be prevented.
第一作者机构：[1]Department of Ophthalmology, University of Ottawa, Ottawa, Canada.
共同第一作者：
通讯作者：
通讯机构：[2]Pediatric Oncology Center, Beijing Children's Hospital, Capital Medical University, Beijing, China.[3]Department of Ophthalmology, Beijing Children's Hospital, Capital Medical University, Beijing, China.[7]Department of Ophthalmology, Hospital for Sick Children, Toronto, Canada.[8]Krembil Research Institute and Techna Institute, University Health Network, Toronto, Canada.[9]Departments Ophthalmology, Medical Biophysics and Molecular Genetics, University of Toronto, Toronto, Canada.
推荐引用方式(GB/T 7714)：
Feng Zhao Xun,Zhao Junyang,Zhang Nan,et al.Adjuvant Chemotherapy Improves Survival for Children With Massive Choroidal Invasion of Retinoblastoma[J].INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.2023,64(11):27.doi:10.1167/iovs.64.11.27.
APA：
Feng Zhao Xun,Zhao Junyang,Zhang Nan,Jin Mei&Gallie Brenda.(2023).Adjuvant Chemotherapy Improves Survival for Children With Massive Choroidal Invasion of Retinoblastoma.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,64,(11)
MLA：
Feng Zhao Xun,et al."Adjuvant Chemotherapy Improves Survival for Children With Massive Choroidal Invasion of Retinoblastoma".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 64..11(2023):27
医学