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Biocompatible Ferrofluid-Based Millirobot for Tumor Photothermal Therapy in Near-Infrared-II Window

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收录情况： ◇ SCIE

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机构： [1]School of Mechanical Engineering & Automation, Beihang University, Beijing, 100191, China. [2]School of Biomedical Engineering, Capital Medical University, Beijing, 100069, China. [3]Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. [4]Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. [5]Department of Diagnostic Ultrasound, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. [6]Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China. [7]CAS Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Beijing, 100190, China. [8]Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100191, China.

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关键词： ferrofluid robots biocompatibility targeted therapy

摘要：

Ferrofluidic robots with excellent deformability and controllability have been intensively studied recently. However, most of these studies are in vitro and the use of ferrofluids for in vivo medicinal applications remains a big challenge. The application of ferrofluidic robots to the body requires the solution of many key problems. In this study, biocompatibility, controllability, and tumor-killing efficacy are considered when creating a ferrofluid-based millirobot for in vivo tumor-targeted therapy. For biocompatibility problems, corn oil is used specifically for the ferrofluid robot. In addition, a control system is built that enables a 3D magnetic drive to be implemented in complex biological media. Using the photothermal conversion property of 1064 nm, the ferrofluid robot can kill tumor cells in vitro; inhibit tumor volume, destroy the tumor interstitium, increase tumor cell apoptosis, and inhibit tumor cell proliferation in vivo. This study provides a reference for ferrofluid-based millirobots to achieve targeted therapies in vivo.© 2023 Wiley-VCH GmbH.

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出版当年[2022]版：

大类 | 1 区

工程技术

小类 | 1 区工程：生物医学 2 区材料科学：生物材料 2 区纳米科技

最新[2025]版：

大类 | 2 区

医学

小类 | 2 区工程：生物医学 2 区材料科学：生物材料 2 区纳米科技

JCR分区：

出版当年[2021]版：

Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS Q1 NANOSCIENCE & NANOTECHNOLOGY

最新[2023]版：

Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS Q1 NANOSCIENCE & NANOTECHNOLOGY

影响因子： 10 最新[2023版] 11.3 最新五年平均 11.092 出版当年[2021版] 10.782 出版当年五年平均 9.933 出版前一年[2020版] 10 出版后一年[2022版]

第一作者：

第一作者机构： [1]School of Mechanical Engineering & Automation, Beihang University, Beijing, 100191, China.

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通讯作者：

通讯机构： [1]School of Mechanical Engineering & Automation, Beihang University, Beijing, 100191, China. [8]Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100191, China.

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Biocompatible Ferrofluid-Based Millirobot for Tumor Photothermal Therapy in Near-Infrared-II Window

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