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Direct quantification of optic nerve blood flow by 3D pseudo-continuous arterial spin labeling

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收录情况： ◇ SCIE

作者：
Wang Qian[1] * ; Li Ligeng[4] * ; Wang Huaizhou[2] ; Chen Weiwei[2] ; Yang Bingbing[1] ; Qu Xiaoxia[1] ; Sun Yunxiao[2] ; Chai Zihan[1] ; Li Ting[1] ; Chen Jianhong[3] ; Meng Gang[4] ; Gong Xiangyu[4] ; Wang Ningli[2,*1] ; Xian Junfang[1,*2] ;
机构： [1]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China [2]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University.Beijing Ophthalmology & Visual Sciences Key Laboratory, China c Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical University, Beijing, China [3]AnImage (Beijing) Technology Co., Ltd., Beijing, China
出处：
DOI： 10.1016/j.jneumeth.2023.110007
ISSN：

关键词： Optic nerve Blood flow Three-dimensional pseudocontinuous arterial spin labeling NnFormer

摘要：
Blood perfusion of the optic nerve (ON) plays a key role in many optic neuropathies. Microvascular changes precede or accompany neuronal changes, and detecting these changes at an early stage may facilitate early treatment to avoid blindness. However, the quantification of ON blood perfusion remains a challenge. This study aimed to evaluate the viability of three-dimensional pseudocontinuous arterial spin labelling (3D-pCASL) MRI for the quantification of ON blood flow (BF).The ON segmentation was performed using nnFormer on a cohort of ten participants (4 males, 6 females, 25-59 years old). Subsequently, the mean BF of each ON segment was calculated using whole brain 3D-pCASL image data.The average ON-BF values of the left and right intraorbital segments, left and right intracanalicular segments, left and right intracranial segments, optic chiasma, and left and right optic tract were 41.308 mL/100 g/min, 43.281 mL/100 g/min, 53.188 mL/100 g/min, 57.202 mL/100 g/min, 45.089 mL/100 g/min, 49.554 mL/100 g/min, 42. 326 mL/100 g/min, 43.831 mL/100 g/min and 45.176 mL/100 g/min, respectively. The ON-BF correlated with cerebral BF (r = 0.503, p = 0.024).The 3D-pCASL can measure tissue microvascular blood perfusion in absolute quantitative units with good test-retest repeatability over a wide field of view and without restrictions on depth. The use of the nnFormer makes the measurement easy, objective and reproducible.The study showed that, 3D-pCASL may be a promising tool for detecting abnormal ON-BF. In particular, 3D-pCASL coupled with the nnFormer provides an objective, reproducible, and reliable method to quantify BF in ON.Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

基金：
National Natural Science Foundation of China [grant numbers 81901719, 81871340 and 82071906]. Beijing Hospitals Authority Youth Programme [grant number QML20210205]. Beijing Municipal Administration of Hospitals’ Ascent Plan [grant number DFL20190203]. Beijing Nova Program [grant number No.20230484460].
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外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 4 区 医学
小类 | 4 区 生化研究方法 4 区 神经科学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 生化研究方法 4 区 神经科学
JCR分区：
出版当年[2022]版：
Q3 BIOCHEMICAL RESEARCH METHODS Q3 NEUROSCIENCES
最新[2023]版：
Q2 BIOCHEMICAL RESEARCH METHODS Q3 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China [2]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University.Beijing Ophthalmology & Visual Sciences Key Laboratory, China c Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical University, Beijing, China [*1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, No.1 Dongjiaominxiang Street, Dongcheng District, Beijing 100730, China. [*2]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, No.1 of Dongjiaominxiang Street, Dongcheng District, Beijing 100730, China.
推荐引用方式(GB/T 7714)：
Wang Qian,Li Ligeng,Wang Huaizhou,et al.Direct quantification of optic nerve blood flow by 3D pseudo-continuous arterial spin labeling[J].JOURNAL OF NEUROSCIENCE METHODS.2024,401:110007.doi:10.1016/j.jneumeth.2023.110007.
APA：
Wang Qian,Li Ligeng,Wang Huaizhou,Chen Weiwei,Yang Bingbing...&Xian Junfang.(2024).Direct quantification of optic nerve blood flow by 3D pseudo-continuous arterial spin labeling.JOURNAL OF NEUROSCIENCE METHODS,401,
MLA：
Wang Qian,et al."Direct quantification of optic nerve blood flow by 3D pseudo-continuous arterial spin labeling".JOURNAL OF NEUROSCIENCE METHODS 401.(2024):110007

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