个人科研网厅 | | 帮助
高级检索
当前位置： 首页 > 详情页

Arterial spin labeling reveals disordered cerebral perfusion and cerebral blood flow-based functional connectivity in primary open-angle glaucoma

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Wang Qian[1] * ; Qu Xiaoxia[1] ; Wang Huaizhou[2,3] ; Chen Weiwei[2,3] ; Sun Yunxiao[2,3] ; Li Ting[1] ; Chen Jianhong[4] ; Wang Yang[5] ; Wang Ningli[2,3] ; Xian Junfang[1] ;
机构： [1]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, NO.1 of Dongjiaominxiang Street, Dongcheng District, Beijing 100730, China [2]Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, NO.1 Dongjiaominxiang Street, Dongcheng District, Beijing 100730, China [3]Beijing Institute of Ophthalmology, Capital Medical University, Beijing Tongren Hospital, 17 Hougou Lane, Chongwenmen, Beijing 100005, China [4]Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical University, Beijing, China [5]Department of Radiology, Medical College of Wisconsin, Milwaukee, WI, USA
出处：
DOI： 10.1007/s11682-023-00813-2
ISSN：

关键词： Arterial spin labeling Cerebral blood flow Connectivity Magnetic resonance imaging Primary open- angle glaucoma

摘要：
Primary open-angle glaucoma (POAG) is a widespread neurodegenerative condition affecting brain regions involved in visual processing, somatosensory processing, motor control, emotional regulation and cognitive functions. Cerebral hemodynamic dysfunction contributes to the pathogenesis of glaucomatous neurodegeneration. We aimed to investigate cerebral blood flow (CBF) redistributed patterns in visual and higher-order cognitive cortices and its relationship with clinical parameters in POAG, and we hypothesized that CBF changes together across regions within the same functional network.Forty-five POAG patients and 23 normal controls underwent three-dimensional pseudocontinuous arterial spin labeling MRI to measure the resting-state CBF. Group comparisons of CBF and correlations between CBF changes and ophthalmological and neuropsychological indices were assessed. We determined CBF-based functional connectivity (CBFC) by calculating the correlations between specific regions and all other brain voxels and compared CBFC differences between groups.The patients exhibited decreased CBF in visual cortices, postcentral gyrus, inferior parietal lobule and cerebellum and increased CBF in medial, middle, and superior frontal gyri, as well as the insula. The reduced CBF in the visual cortices positively correlated with visual field defect (r = 0.498, p = 0.001) in POAG patients, while the increased CBF in the right medial frontal gyrus was negatively associated with the visual field defect (r = -0.438, p = 0.004) and positively associated with the cup-to-disc ratio (r = 0.469, p = 0.002). POAG patients showed negative connections weakening or converting to mild positive connections, as well as positive connections converting to negative connections.Regional and interregional CBF properties confirmed that the aberrant brain regions extend beyond the visual pathway, including the somatosensory, emotional and cognitive networks, which highlights the importance of cerebral hemodynamic dysfunction in the pathophysiology of spreading neurodegeneration in POAG.© 2023. The Author(s).

基金：
Supported by the National Natural Science Foundation of China under Grants 81901719, 81871340, 82071906 and 81701 666. Bejing Municipal Administration of Hospital's Youth Program under Grants QML202 10205. Beijing Municipal Administration of Hospi- tals' Ascent Plan [DFL20190203 ].Sponsored by Beijing Nova Program (No.20230484460).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 3 区 医学
小类 | 3 区 神经成像
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 神经成像
JCR分区：
出版当年[2022]版：
Q2 NEUROIMAGING
最新[2023]版：
Q2 NEUROIMAGING

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, NO.1 of Dongjiaominxiang Street, Dongcheng District, Beijing 100730, China
通讯作者：
通讯机构： [2]Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, NO.1 Dongjiaominxiang Street, Dongcheng District, Beijing 100730, China [3]Beijing Institute of Ophthalmology, Capital Medical University, Beijing Tongren Hospital, 17 Hougou Lane, Chongwenmen, Beijing 100005, China
推荐引用方式(GB/T 7714)：
Wang Qian,Qu Xiaoxia,Wang Huaizhou,et al.Arterial spin labeling reveals disordered cerebral perfusion and cerebral blood flow-based functional connectivity in primary open-angle glaucoma[J].BRAIN IMAGING AND BEHAVIOR.2024,18(1):231-242.doi:10.1007/s11682-023-00813-2.
APA：
Wang Qian,Qu Xiaoxia,Wang Huaizhou,Chen Weiwei,Sun Yunxiao...&Xian Junfang.(2024).Arterial spin labeling reveals disordered cerebral perfusion and cerebral blood flow-based functional connectivity in primary open-angle glaucoma.BRAIN IMAGING AND BEHAVIOR,18,(1)
MLA：
Wang Qian,et al."Arterial spin labeling reveals disordered cerebral perfusion and cerebral blood flow-based functional connectivity in primary open-angle glaucoma".BRAIN IMAGING AND BEHAVIOR 18..1(2024):231-242

相关文献

[1]Retinotopic Changes in the Gray Matter Volume and Cerebral Blood Flow in the Primary Visual Cortex of Patients With Primary Open-Angle Glaucoma [2]Reduced Cerebral Blood Flow in the Visual Cortex and Its Correlation With Glaucomatous Structural Damage to the Retina in Patients With Mild to Moderate Primary Open-angle Glaucoma [3]Altered coupling of cerebral blood flow and functional connectivity strength in visual and higher order cognitive cortices in primary open angle glaucoma [4]Association between white matter hyperintensities and altered cerebral blood flow in maintenance hemodialysis patients: a longitudinal study [5]Altered coupling of cerebral blood flow and functional connectivity strength in visual and higher order cognitive cortices in primary open angle glaucoma. [6]Reduced Functional and Anatomic Interhemispheric Homotopic Connectivity in Primary Open-Angle Glaucoma: A Combined Resting State-fMRI and DTI Study [7]Altered stability of dynamic brain functional architecture in primary open-angle glaucoma: a surface-based resting-state fMRI study [8]原发性开角型青光眼患者视放射的扩散张量成像价值分析 [9]Altered Amplitude of Low-Frequency Fluctuation in Primary Open-Angle Glaucoma: A Resting-State fMRI Study [10]Neurovascular coupling dysfunction associated with inflammatory factors in sudden sensorineural hearing loss

资源点击量：23459 今日访问量：6 总访问量：1282 更新日期：2025-04-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学附属北京同仁医院 技术支持：重庆聚合科技有限公司 地址：北京市东城区东交民巷1号(100730)