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Shared immune metabolic reprogramming between COVID-19 patients in the intensive care unit and ischemic stroke: a pilot study

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机构： [1]Department of Neurosurgery, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. [2]Department of Neurosurgery, Shanghai Public Health Clinical Center, Shanghai, China. [3]Department of Neurosurgery, Shanghai Pudong New Area People's Hospital, Shanghai, China.

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关键词： ischemic stroke COVID-19 complement hypoxia single cell RNA sequencing Gene Expression Omnibus (GEO)

摘要：

To investigate shared gene signatures between COVID-19 and ischemic stroke.Combining the existing bulk RNA sequencing and single-cell RNA sequencing (scRNA-seq) data for COVID-19 to obtain a more comprehensive understanding of the role of dysregulated metabolism.A total of 19 up-regulated differentially expressed genes (DEGs) and 24 down-regulated genes were selected for subsequent analyses. Nine genes were finally identified with the machine learning method as a potential diagnostic model in both ischemic stroke and COVID-19. In addition, the hub genes were related to both immune infiltration and metabolic pathways.Our study revealed the common molecular profile of COVID-19 and ischemic stroke.Copyright: © 2023 Termedia & Banach.

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出版当年[2022]版：

大类 | 3 区医学

小类 | 3 区医学：内科

最新[2023]版：

大类 | 4 区医学

小类 | 3 区医学：内科

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出版当年[2021]版：

Q2 MEDICINE, GENERAL & INTERNAL

最新[2023]版：

Q1 MEDICINE, GENERAL & INTERNAL

影响因子： 3 最新[2023版] 3.2 最新五年平均 3.707 出版当年[2021版] 3.757 出版当年五年平均 3.318 出版前一年[2020版] 3.9 出版后一年[2022版]

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第一作者机构： [1]Department of Neurosurgery, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

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