机构：[1]Ufa Eye Research Institute, Ufa, Russia[2]Department of Ophthalmology, University Hospital Heidelberg, Heidelberg, Germany[3]Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany[4]Institute of Molecular and Clinical Ophthalmology IOB, Basel, Switzerland[5]Singapore Eye Research Institute, Singapore, Singapore[6]Tsinghua Medicine, Tsinghua University, Beijing, China[7]New York Eye and Ear Infirmary of Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, United States
To assess the prevalence of myopic macular degeneration (MMD) in very old individuals.The population-based Ural Very Old Study (UVOS) included 1526 (81.1%) of 1882 eligible inhabitants aged ≥85 years. Assessable fundus images were available for 930 (60.9%) individuals (mean age, 88.6 ± 2.7 years). MMD was defined by macular patchy atrophies (i.e., MMD stage 3 and 4 as defined by the Pathologic Myopia Study Group).MMD prevalence was 21 of 930 (2.3%; 95% CI, 1.3-3.3), with 10 individuals (1.1%; 95% CI, 0.4-1.7) having MMD stage 3 and 11 participants (1.2%; 95% CI, 0.5-1.9) MMD stage 4 disease. Within MMD stage 3 and 4, prevalence of binocular moderate to severe vision impairment was 4 of 10 (40%; 95% CI, 31-77) and 7 of 11 (64%; 95% CI, 30-98), respectively, and the prevalence of binocular blindness was 2 of 10 (20%; 95% CI, 0-50) and 3 of 11 (27%; 95% CI, 0-59), respectively. In minor myopia (axial length, 24.0 to <24.5 mm), moderate myopia (axial length, 24.5 to <26.5 mm), and high myopia (axial length, ≥26.5 mm), MMD prevalence in the right eyes was 0 of 46 eyes (0%), 3 of 40 eyes (8%; 95% CI, 0-16), and 7 of 9 (78%; 95% CI, 44-100), respectively; MMD prevalence in the left eyes was 1 in 48 eyes (2%; 95% CI, 0-6), 4 of 36 eyes (11%; 95% CI, 0-22), and 3 of 4 eyes (75%; 95% CI, 0-100), respectively. In multivariable analysis, a higher MMD prevalence (odds ratio, 8.89; 95% CI, 3.43-23.0; P < 0.001) and higher MMD stage (beta, 0.45; B, 19; 95% CI, 0.16-0.22; P < 0.001) were correlated with longer axial length but not with any other ocular or systemic parameter.MMD prevalence (stages 3 and 4) in very old individuals increased 8.89-fold for each mm axial length increase, with a prevalence of ≥75% in highly myopic eyes. In old age, highly myopic individuals have a high risk of eventually developing MMD with marked vision impairment.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|2 区医学
小类|2 区眼科学
最新[2025]版：
大类|2 区医学
小类|2 区眼科学
第一作者：
第一作者机构：[1]Ufa Eye Research Institute, Ufa, Russia[*1]Ufa Eye Research Institute, 90 Pushkin Street, Ufa 450077, Russia
通讯作者：
通讯机构：[1]Ufa Eye Research Institute, Ufa, Russia[4]Institute of Molecular and Clinical Ophthalmology IOB, Basel, Switzerland[5]Singapore Eye Research Institute, Singapore, Singapore[6]Tsinghua Medicine, Tsinghua University, Beijing, China[7]New York Eye and Ear Infirmary of Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, United States[*1]Ufa Eye Research Institute, 90 Pushkin Street, Ufa 450077, Russia[*2]Department of Ophthalmology, Medical Faculty Mannheim, Theodor-Kutzerufer 1, Mannheim 68167, Germany
推荐引用方式(GB/T 7714)：
Bikbov Mukharram M,Gilmanshin Timur R,Kazakbaeva Gyulli M,et al.Prevalence of Myopic Maculopathy Among the Very Old: The Ural Very Old Study[J].Investigative Ophthalmology & Visual Science.2024,65(3):29.doi:10.1167/iovs.65.3.29.
APA：
Bikbov Mukharram M,Gilmanshin Timur R,Kazakbaeva Gyulli M,Panda-Jonas Songhomitra&Jonas Jost B.(2024).Prevalence of Myopic Maculopathy Among the Very Old: The Ural Very Old Study.Investigative Ophthalmology & Visual Science,65,(3)
MLA：
Bikbov Mukharram M,et al."Prevalence of Myopic Maculopathy Among the Very Old: The Ural Very Old Study".Investigative Ophthalmology & Visual Science 65..3(2024):29
