Aims The present study aimed to investigate the accuracy of the Glunovo (R) real-time continuous glucose monitoring system (rtCGMS). Methods We conducted a 14-day interstitial glucose level monitoring using Glunovo (R) rtCGMS on thirty hospitalized patients with type 2 diabetes. The flash glucose monitoring (FGM) was used as a self-control. Consistency tests, error grid analysis, and calculation of the mean absolute relative difference (MARD) were performed using R software to assess the accuracy of Glunovo (R) rtCGMS. Results Glunovo (R) exhibited an overall MARD value of 8.89% during hospitalization, compared to 10.42% for FGM. The overall percentages of glucose values within +/- 10%/10, +/- 15%/15, +/- 20%/20, +/- 30%/30, and +/- 40%/40 of the venous blood glucose reference value were 63.34%, 81.31%, 90.50%, 97.29%, and 99.36% for Glunovo (R), respectively, compared with 61.58%, 79.63%, 88.31%, 96.22% and 99.23% for FGM. The Clarke Error Grid Analysis showed that 99.61% of Glunovo (R) glucose pairs and 100.00% of FGM glucose pairs within zones A and B. Conclusion Our study confirms the superior accuracy of Glunovo (R) in monitoring blood glucose levels among hospitalized patients with type 2 diabetes.