Purpose: This study investigates whether virtual distant viewing technology can prevent nearwork-induced ocular parameter changes. Methods: Twenty-six volunteers read a textbook on one day and the same content on a virtual distant viewing display on another day based on a randomization sequence, with both reading sessions at 33 cm for 4 hours. Visual acuity, diopter, ocular biology, visual fatigue, and accommodative function before and after the nearwork, as well as the number of pages read, were recorded. Results: After 4 hours of nearwork in the textbook group, the spherical equivalent refraction decreased from -3.13 +/- 2.65 D to -3.32 +/- 2.70 D (P < 0.001), corneal thickness decreased from 531.6 +/- 33.5 mu m to 528.9 +/- 33.0 mu m (P = 0.015), anterior chamber depth decreased from 3.65 +/- 0.35 mm to 3.60 +/- 0.30 mm (P = 0.002), accommodative facility increased from 15.1 +/- 3.5 to 16.4 +/- 3.9 (P = 0.018), and subjective visual fatigue increased from 14.0 +/- 9.2 to 19.3 +/- 7.6 (P = 0.002); no significant changes were seen in the other parameters. In the virtual distant viewing group, the spherical equivalent refraction (from -3.17 +/- 2.60 D to -3.11 +/- 2.73 D, P = 0.427), corneal thickness (from 531.9 +/- 32.8 mu m to 529.7 +/- 33.2 mu m, P = 0.054), and anterior chamber depth (from 3.67 +/- 0.35 mm to 3.69 +/- 0.32 mm, P = 0.331) did not show significant changes, whereas accommodative facility increased from 14.7 +/- 5.8 to 15.9 +/- 5.5 (P = 0.042) and subjective visual fatigue increased from 13.5 +/- 8.4 to 18.9 +/- 8.6 (P = 0.002). In addition, choroidal thickness (from 217.7 +/- 76.0 mu m to 243.0 +/- 85.0 mu m, P = 0.043), positive relative accommodation (from -2.32 +/- 1.07 D to -2.85 +/- 0.89 D, P = 0.007), and amplitude of accommodation (from 7.26 +/- 1.41 D to 7.89 +/- 1.69 D, P = 0.022) also significantly increased in the virtual distant viewing group. The textbook group and the virtual distant viewing group read 176.0 +/- 133.1 pages and 188.0 +/- 102.0 pages, respectively, and there was no significant difference between the two groups (P = 0.708). Conclusion: Virtual distant viewing technology can prevent the increase in myopia degree due to nearwork and improve accommodation function without increasing visual fatigue.