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Current research and future strategies for the management of vision-threatening diabetic retinopathy

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机构： [1]Department of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Centre for Diabetes, Shanghai International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases, Shanghai, China [2]Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy [3]Eye Clinic, IRCCS MultiMedica, Milan, Italy [4]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore [5]Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore [6]Department of Ophthalmology, Odense University Hospital, Odense, Denmark [7]Department of Clinical Research, University of Southern Denmark, Odense, Denmark [8]Department of Ophthalmology, Vestfold Hospital Trust, T鴠nsberg, Norway [9]NIHR Moorfields Clinical Research Facility, Moorfields Eye Hospital, London, United Kingdom [10]Tsinghua Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China

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关键词： Diabetic retinopathy Biomarker in diabetic retinopathy Screening of referable diabetic retinopathy Treatment strategies for vision-threatening diabetic retinopathy

摘要：

Diabetic retinopathy (DR) is a major ocular complication of diabetes and the leading cause of blindness and visual impairment, particularly among adults of working-age adults. Although the medical and economic burden of DR is significant and its global prevalence is expected to increase, particularly in low- and middle-income countries, a large portion of vision loss caused by DR remains preventable through early detection and timely intervention. This perspective reviewed the latest developments in research and innovation in three areas, first novel biomarkers (including advanced imaging modalities, serum biomarkers, and artificial intelligence technology) to predict the incidence and progression of DR, second, screening and early detection of referable DR and vision-threatening DR (VTDR), and finally, novel therapeutic strategies for VTDR, including diabetic macular oedema (DME), with the goal of reducing diabetic blindness.Copyright © 2024. Published by Elsevier Inc.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 2 区眼科学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区眼科学

第一作者：

第一作者机构： [1]Department of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Centre for Diabetes, Shanghai International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases, Shanghai, China

通讯作者：

通讯机构： [4]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore [10]Tsinghua Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China

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