机构：[1]Department of Biochemistry and Molecular Biology, Capital Medical University, Beijing, China[2]Department of Otolaryngology‐Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Chronic Disease Research Center, NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Institute of Laboratory Animal Sciences, CAMS & PUMC, Beijing, China
Salivary adenoid cystic carcinoma (SACC) with a unique MYB-NFIB fusion has been considered an "immune-cold" tumor, but the mechanisms behind this remain unclear. In this study, we analyzed the immune status of 29 SACC patients and found that most lung metastases exhibited an immunoinflammatory state, in contrast to the primary SACC tissues. Single-cell sequencing data showed that anergic T-cell types were low in primary inflammatory tissues, while inflammatory metastatic lung tissues had elevated levels of anergic CD8+ natural killer T (NKT)-like cells and low levels of memory T cells. Primary exclusive tissues had high levels of myeloid-derived suppressor cells (MDSCs) and low levels of activated CD8+ NKT-like cells. These data support the fact that metastatic SACC cells might induce a stronger immune response in the lung. Additionally, an in vivo experiment showed that a minimally invasive SACC cell line with higher expression of human leukocyte antigens -B and -C induced NKT cell activation in mice and effectively attenuated the incidence of lung metastases caused by a highly invasive SACC cell line. This suggests that NKT therapy may be active in treating SACC lung metastasis. Conclusively, this study sheds light on the immune microenvironment of SACC and highlights the potential of NKT-based therapy. Our single-cell sequencing data reveals significant differences in the composition of immunocytes, intercellular communication, and signaling molecules between primary inflamed and primary excluded tissues, as well as metastatic lung inflamed tissues from salivary adenoid cystic carcinoma (SACC) patients. Furthermore, the analysis of the animal experimental results demonstrates that CD8 + NK cells have therapeutic potential for inhibiting lung metastasis. image
基金：
Data Center of Management Science,
National Natural Science Foundation of
China ‐ Peking University,
Grant/Award Number: 82173312; Capital
Health Research and Development of
Special Fund, Grant/Award Number:
2022‐2‐2057
语种：
外文
被引次数：
WOS：
第一作者：
第一作者机构：[1]Department of Biochemistry and Molecular Biology, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Biochemistry and Molecular Biology, Capital Medical University, Beijing, China[2]Department of Otolaryngology‐Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China[3]Chronic Disease Research Center, NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Institute of Laboratory Animal Sciences, CAMS & PUMC, Beijing, China[*1]Chronic Disease Research Center, NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Institute of Laboratory Animal Sciences, CAMS & PUMC, 5 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China[*2]Department of Otolaryngology‐Head and Neck Surgery, Capital Medical University, No. 1, Dongjiaominxiang St, Dongcheng District, Beijing 100730, China[*3]Department of Biochemistry and Molecular Biology, Capital Medical University, No. 10 Xitoutiao, You An Men, Beijing 100069, China.
推荐引用方式(GB/T 7714)：
Feng Ge-xuan,Zhou Meng-jiao,Cao Lin,et al.NKT cells contribute to alleviating lung metastasis in adenoid cystic carcinoma[J].MEDCOMM-ONCOLOGY.2023,2(2):doi:10.1002/mog2.29.
APA：
Feng, Ge-xuan,Zhou, Meng-jiao,Cao, Lin,Ma, Ting-yao,Wang, Xue-lian...&Kong, Lu.(2023).NKT cells contribute to alleviating lung metastasis in adenoid cystic carcinoma.MEDCOMM-ONCOLOGY,2,(2)
MLA：
Feng, Ge-xuan,et al."NKT cells contribute to alleviating lung metastasis in adenoid cystic carcinoma".MEDCOMM-ONCOLOGY 2..2(2023)
