机构：[1]Yong Loo Lin School of Medicine, National University of Singapore, Singapore[2]Ophthalmic Engineering & Innovation Laboratory, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore[3]Eye-ACP, Duke-NUS Medical School, Singapore, Singapore[4]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore[5]Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, School of Engineering Medicine, Beihang University, Beijing, China[6]Institute for Molecular and Clinical Ophthalmology, Basel, Switzerland[7]Department of Ophthalmology, Columbia University, New York, United States
To compare changes in macular curvature following acute IOP elevation across a range of myopic conditions.We studied 328 eyes from 184 subjects, comprising 32 emmetropic controls (between +2.75 and -2.75 diopters), 50 eyes with high myopia (<-5 diopters; HM), 108 highly myopic with glaucoma (HMG) and 105 pathologic myopia (PM) eyes, and 33 PM with staphyloma (PM+S) eyes. For each eye, we imaged the macula using optical coherence tomography (OCT) under the baseline condition and under acute IOP elevation (to ∼40 mm Hg) achieved through ophthalmodynamometry. We manually aligned the scans (baseline and IOP elevation) using three vascular landmarks in the macula tissue. We then automatically segmented the sclera and the choroid tissues using a deep learning algorithm and extracted the sclera-choroid interface. We calculated the macula curvatures, determined by the radius of curvature of the sclera-choroid interface in the nasal-temporal and superior-inferior direction. Differences in macula curvatures between baseline and elevated IOP scans were calculated at corresponding locations, and the mean curvature difference was reported for each eye.IOP elevation resulted in a significantly higher macula curvature change along the nasal-temporal direction in the PM+S (13.5 ± 8.2 × 10-5 µm-1), PM (9.0 ± 7.9 × 10-5 µm-1), and HMG (5.2 ± 5.1 × 10-5 µm-1) eyes as compared to HM (3.1 ± 2.7 × 10-5 µm-1) eyes (all P < 0.05). Interestingly, HM and HMG eyes had the same curvature change in the nasal-temporal direction as emmetropic control eyes (4.2 ± 4.3 × 10-5 µm-1).Our findings indicate that the macula in HMG, PM, and PM+S eyes showed greater curvature changes under IOP elevation compared to HM and emmetropic eyes. These preliminary results suggest that HM eyes with conditions such as glaucoma or staphyloma are more sensitive to acute IOP elevation.
基金：
Supported by National Medical Research Council (MOH-000531-
00 [QVH] and MOH-001103-00 [QVH]); the SERI-Lee Foundation
(LF0621-1 [QVH]); the Lee Foundation (TLF1021-3
[QVH] and TLF 0322-8 [QVH]); the SingHealth Foundation-
SNEC (R1499/82/2017 [QVH]) in Singapore; the Singapore
Ministry of Education, Academic Research Funds, Tier 2
(R-397-000-280-112; R-397-000-308-112); Singapore Ministry
of Education, Academic Research Funds, Tier 1 (R-397000-
294-114); the National Medical Research Council (Grant
NMRC/STAR/0023/2014); National Natural Science Foundation
of China (12002025); Tracking and Reducing Glaucoma Blindness
with Emerging Technologies (TARGET, MOH-OFLCG21jun-
0003); and the Retinal Analytics through Machine learning
aiding Physics (RAMP) project supported by the National
Research Foundation, Prime Minister’s Office, Singapore, under
its Intra-Create Thematic Grant “Intersection of Engineering
and Health” (NRF2019-THE002-0006), awarded to the Singapore
MIT Alliance for Research and Technology (SMART) Centre.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|2 区医学
小类|2 区眼科学
最新[2025]版：
大类|2 区医学
小类|2 区眼科学
第一作者：
第一作者机构：[1]Yong Loo Lin School of Medicine, National University of Singapore, Singapore[2]Ophthalmic Engineering & Innovation Laboratory, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
通讯作者：
通讯机构：[1]Yong Loo Lin School of Medicine, National University of Singapore, Singapore[2]Ophthalmic Engineering & Innovation Laboratory, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore[3]Eye-ACP, Duke-NUS Medical School, Singapore, Singapore[4]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore[6]Institute for Molecular and Clinical Ophthalmology, Basel, Switzerland[7]Department of Ophthalmology, Columbia University, New York, United States
推荐引用方式(GB/T 7714)：
Chuangsuwanich Thanadet,Tun Tin A,Braeu Fabian A,et al.Comparing IOP-Induced Scleral Deformations in the Myopic and Myopic Glaucoma Spectrums[J].Investigative Ophthalmology & Visual Science.2024,65(13):54.doi:10.1167/iovs.65.13.54.
APA：
Chuangsuwanich Thanadet,Tun Tin A,Braeu Fabian A,Chong Rachel S,Wang Xiaofei...&Hoang Quan V.(2024).Comparing IOP-Induced Scleral Deformations in the Myopic and Myopic Glaucoma Spectrums.Investigative Ophthalmology & Visual Science,65,(13)
MLA：
Chuangsuwanich Thanadet,et al."Comparing IOP-Induced Scleral Deformations in the Myopic and Myopic Glaucoma Spectrums".Investigative Ophthalmology & Visual Science 65..13(2024):54
